node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTAG1A | CTAG1B | ENSP00000469441 | ENSP00000332602 | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | 0.793 |
CTAG1A | MAGEA1 | ENSP00000469441 | ENSP00000349085 | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | 0.865 |
CTAG1A | MAGEC1 | ENSP00000469441 | ENSP00000285879 | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | Melanoma-associated antigen C1; MAGE family member C1 | 0.845 |
CTAG1A | MAGEC2 | ENSP00000469441 | ENSP00000354660 | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family | 0.685 |
CTAG1A | SSX1 | ENSP00000469441 | ENSP00000366118 | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family | 0.670 |
CTAG1B | CTAG1A | ENSP00000332602 | ENSP00000469441 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | 0.793 |
CTAG1B | MAGEA1 | ENSP00000332602 | ENSP00000349085 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | 0.865 |
CTAG1B | MAGEC1 | ENSP00000332602 | ENSP00000285879 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | Melanoma-associated antigen C1; MAGE family member C1 | 0.858 |
CTAG1B | MAGEC2 | ENSP00000332602 | ENSP00000354660 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family | 0.686 |
CTAG1B | SSX1 | ENSP00000332602 | ENSP00000366118 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family | 0.670 |
CTAG2 | MAGEA1 | ENSP00000247306 | ENSP00000349085 | Cancer/testis antigen 2 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | 0.756 |
CTAG2 | MAGEC1 | ENSP00000247306 | ENSP00000285879 | Cancer/testis antigen 2 | Melanoma-associated antigen C1; MAGE family member C1 | 0.720 |
CTAG2 | MAGEC2 | ENSP00000247306 | ENSP00000354660 | Cancer/testis antigen 2 | Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family | 0.651 |
CTAG2 | SSX1 | ENSP00000247306 | ENSP00000366118 | Cancer/testis antigen 2 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family | 0.670 |
MAGEA1 | CTAG1A | ENSP00000349085 | ENSP00000469441 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family | 0.865 |
MAGEA1 | CTAG1B | ENSP00000349085 | ENSP00000332602 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family | 0.865 |
MAGEA1 | CTAG2 | ENSP00000349085 | ENSP00000247306 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | Cancer/testis antigen 2 | 0.756 |
MAGEA1 | MAGEC1 | ENSP00000349085 | ENSP00000285879 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | Melanoma-associated antigen C1; MAGE family member C1 | 0.447 |
MAGEA1 | MAGEC2 | ENSP00000349085 | ENSP00000354660 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family | 0.418 |
MAGEA1 | SSX1 | ENSP00000349085 | ENSP00000366118 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family | 0.685 |