node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA3 | ABCC4 | ENSP00000301732 | ENSP00000366084 | ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | 0.703 |
ABCA3 | MRPS7 | ENSP00000301732 | ENSP00000245539 | ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | 0.485 |
ABCC4 | ABCA3 | ENSP00000366084 | ENSP00000301732 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family | 0.703 |
ABCC4 | ABCE1 | ENSP00000366084 | ENSP00000296577 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family | 0.727 |
ABCC4 | ABCG4 | ENSP00000366084 | ENSP00000481728 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis; ATP binding cassette subfamily G | 0.703 |
ABCC4 | ENSG00000257046 | ENSP00000366084 | ENSP00000441269 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Solute carrier organic anion transporter family member; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | 0.685 |
ABCC4 | MRPS7 | ENSP00000366084 | ENSP00000245539 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | 0.799 |
ABCC4 | NR1H4 | ENSP00000366084 | ENSP00000447149 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Bile acid receptor; Isoform 4- Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA; Belongs to the nuclear hormone receptor family. NR1 subfamily | 0.736 |
ABCC4 | SLC22A8 | ENSP00000366084 | ENSP00000337335 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Solute carrier family 22 member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA); Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family | 0.795 |
ABCC4 | SLCO1B1 | ENSP00000366084 | ENSP00000256958 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Solute carrier organic anion transporter family member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | 0.686 |
ABCC4 | SLCO1B3 | ENSP00000366084 | ENSP00000261196 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Solute carrier organic anion transporter family member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | 0.685 |
ABCC4 | SNX27 | ENSP00000366084 | ENSP00000357836 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus- following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...] | 0.774 |
ABCE1 | ABCC4 | ENSP00000296577 | ENSP00000366084 | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | 0.727 |
ABCE1 | MRPS7 | ENSP00000296577 | ENSP00000245539 | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly; Belongs to the ABC transporter superfamily. ABCE family | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | 0.818 |
ABCG4 | ABCC4 | ENSP00000481728 | ENSP00000366084 | ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis; ATP binding cassette subfamily G | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | 0.703 |
ENSG00000257046 | ABCC4 | ENSP00000441269 | ENSP00000366084 | Solute carrier organic anion transporter family member; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C | 0.685 |
ENSG00000257046 | MRPS7 | ENSP00000441269 | ENSP00000245539 | Solute carrier organic anion transporter family member; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | 0.452 |
ENSG00000257046 | NR1H4 | ENSP00000441269 | ENSP00000447149 | Solute carrier organic anion transporter family member; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | Bile acid receptor; Isoform 4- Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DCA), SLC51B/OSTB (inducible by unconjugated CDCA and DCA) and FABP6/IBAP; most efficient isoform compared to isoforms 1 to 3; not inducible by taurine- and glycine-amidated CDCA; Belongs to the nuclear hormone receptor family. NR1 subfamily | 0.563 |
ENSG00000257046 | SLC22A8 | ENSP00000441269 | ENSP00000337335 | Solute carrier organic anion transporter family member; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family | Solute carrier family 22 member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA); Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family | 0.797 |
MRPS7 | ABCA3 | ENSP00000245539 | ENSP00000301732 | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family | ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter superfamily. ABCA family | 0.485 |