C9orf40 protein (human) - STRING database

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C9orf40

Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40 (194 aa)

Predicted Functional Partners:

C9orf41

0.590

ZSWIM3

0.510

TRMT1L

0.495

DNAJC9

0.495

MPHOSPH6

0.455

CCSAP

0.445

SMC2

0.444

hCG_401294

0.443

ZNF507

0.442

STK35

0.428

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C9orf40	C9orf41	ENSP00000366050	ENSP00000366030	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	Carnosine N-methyltransferase; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L- histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA- His)	0.590
C9orf40	CCSAP	ENSP00000366050	ENSP00000284617	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity)	0.445
C9orf40	DNAJC9	ENSP00000366050	ENSP00000362041	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	0.495
C9orf40	MPHOSPH6	ENSP00000366050	ENSP00000258169	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D	0.455
C9orf40	SMC2	ENSP00000366050	ENSP00000286398	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	0.444
C9orf40	STK35	ENSP00000366050	ENSP00000370891	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	Serine/threonine kinase 35; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family	0.428
C9orf40	TRMT1L	ENSP00000366050	ENSP00000356476	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	TRMT1-like protein; May play a role in motor coordination and exploratory behavior; tRNA methyltransferases	0.495
C9orf40	ZNF507	ENSP00000366050	ENSP00000312277	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	Zinc finger protein 507; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.442
C9orf40	ZSWIM3	ENSP00000366050	ENSP00000255152	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	Zinc finger SWIM-type containing 3	0.510
C9orf40	hCG_401294	ENSP00000366050	ENSP00000482829	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	annotation not available	0.443
C9orf41	C9orf40	ENSP00000366030	ENSP00000366050	Carnosine N-methyltransferase; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L- histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA- His)	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.590
CCSAP	C9orf40	ENSP00000284617	ENSP00000366050	Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity)	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.445
CCSAP	ZSWIM3	ENSP00000284617	ENSP00000255152	Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity)	Zinc finger SWIM-type containing 3	0.429
DNAJC9	C9orf40	ENSP00000362041	ENSP00000366050	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.495
DNAJC9	SMC2	ENSP00000362041	ENSP00000286398	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	0.794
MPHOSPH6	C9orf40	ENSP00000258169	ENSP00000366050	M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3’-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.455
SMC2	C9orf40	ENSP00000286398	ENSP00000366050	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.444
SMC2	DNAJC9	ENSP00000286398	ENSP00000362041	Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily	DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins	0.794
STK35	C9orf40	ENSP00000370891	ENSP00000366050	Serine/threonine kinase 35; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.428
TRMT1L	C9orf40	ENSP00000356476	ENSP00000366050	TRMT1-like protein; May play a role in motor coordination and exploratory behavior; tRNA methyltransferases	Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40	0.495

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