• Version:
  • 11.0 [archived version]
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NMRK1 NMRK1 C9orf40 C9orf40 FBXO28 FBXO28 ZNF483 ZNF483 C9orf41 C9orf41 ELP6 ELP6 CARNS1 CARNS1 LRCH3 LRCH3 RMND5A RMND5A CNDP1 CNDP1 CNDP2 CNDP2
"C9orf41" - Carnosine N-methyltransferase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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C9orf41Carnosine N-methyltransferase; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L- histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA- His) (409 aa)    
Predicted Functional Partners:
CARNS1
Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine (950 aa)
     
 
  0.969
CNDP2
Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N- lactoyl-amino acids from lactat [...] (475 aa)
     
 
  0.948
CNDP1
Carnosine dipeptidase 1; Belongs to the peptidase M20A family (507 aa)
     
 
  0.941
ELP6
Elongator complex protein 6; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (266 aa)
           
  0.701
ZNF483
Zinc finger protein 483; May be involved in transcriptional regulation; SCAN domain containing (744 aa)
       
 
  0.674
LRCH3
Leucine rich repeats and calponin homology domain containing 3 (712 aa)
           
  0.651
RMND5A
Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex (391 aa)
     
 
  0.628
NMRK1
Nicotinamide riboside kinase 1; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3- deazaguanosine; Belongs to the uridine kinase family. NRK subfamily (199 aa)
 
 
   
  0.593
C9orf40
Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40 (194 aa)
           
  0.590
FBXO28
F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other (368 aa)
           
  0.586
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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