node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANGPTL7 | C19orf80 | ENSP00000366015 | ENSP00000479969 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | 0.725 |
ANGPTL7 | C1orf127 | ENSP00000366015 | ENSP00000366203 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Uncharacterized protein C1orf127; Chromosome 1 open reading frame 127 | 0.576 |
ANGPTL7 | CLDN12 | ENSP00000366015 | ENSP00000287916 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.481 |
ANGPTL7 | COL5A2 | ENSP00000366015 | ENSP00000364000 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices (By similarity) | 0.536 |
ANGPTL7 | FAM49B | ENSP00000366015 | ENSP00000429150 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Protein FAM49B; Family with sequence similarity 49 member B | 0.670 |
ANGPTL7 | LPL | ENSP00000366015 | ENSP00000309757 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.540 |
ANGPTL7 | MOB2 | ENSP00000366015 | ENSP00000328694 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L; Belongs to the MOB1/phocein family | 0.504 |
ANGPTL7 | MYOC | ENSP00000366015 | ENSP00000037502 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Myocilin; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migrat [...] | 0.596 |
ANGPTL7 | PCSK2 | ENSP00000366015 | ENSP00000262545 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily | 0.547 |
ANGPTL7 | TXNDC11 | ENSP00000366015 | ENSP00000283033 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation | 0.518 |
C19orf80 | ANGPTL7 | ENSP00000479969 | ENSP00000366015 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | 0.725 |
C19orf80 | LPL | ENSP00000479969 | ENSP00000309757 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | 0.964 |
C1orf127 | ANGPTL7 | ENSP00000366203 | ENSP00000366015 | Uncharacterized protein C1orf127; Chromosome 1 open reading frame 127 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | 0.576 |
CLDN12 | ANGPTL7 | ENSP00000287916 | ENSP00000366015 | Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | 0.481 |
CLDN12 | FAM49B | ENSP00000287916 | ENSP00000429150 | Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | Protein FAM49B; Family with sequence similarity 49 member B | 0.592 |
COL5A2 | ANGPTL7 | ENSP00000364000 | ENSP00000366015 | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices (By similarity) | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | 0.536 |
FAM49B | ANGPTL7 | ENSP00000429150 | ENSP00000366015 | Protein FAM49B; Family with sequence similarity 49 member B | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | 0.670 |
FAM49B | CLDN12 | ENSP00000429150 | ENSP00000287916 | Protein FAM49B; Family with sequence similarity 49 member B | Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins | 0.592 |
LPL | ANGPTL7 | ENSP00000309757 | ENSP00000366015 | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like | 0.540 |
LPL | C19orf80 | ENSP00000309757 | ENSP00000479969 | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family | 0.964 |