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  • 11.0 [archived version]
STRINGSTRING
PCSK2 PCSK2 COL5A2 COL5A2 C1orf127 C1orf127 MOB2 MOB2 FAM49B FAM49B ANGPTL7 ANGPTL7 CLDN12 CLDN12 TXNDC11 TXNDC11 MYOC MYOC LPL LPL C19orf80 C19orf80
"ANGPTL7" - Angiopoietin-related protein 7 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ANGPTL7Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like (346 aa)    
Predicted Functional Partners:
C19orf80
Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding- required to direct fatty acids to adipose tissue for storage in the fed state (By similarity); Belongs to the ANGPTL8 family (198 aa)
           
  0.725
FAM49B
Protein FAM49B; Family with sequence similarity 49 member B (324 aa)
           
  0.670
MYOC
Myocilin; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migrat [...] (504 aa)
     
   
  0.596
C1orf127
Uncharacterized protein C1orf127; Chromosome 1 open reading frame 127 (823 aa)
           
  0.576
PCSK2
Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells; Belongs to the peptidase S8 family. Furin subfamily (638 aa)
           
  0.547
LPL
Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity); Belongs to the AB hydrolase superfamily. Lipase family (475 aa)
           
  0.540
COL5A2
Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue- specific matrices (By similarity) (1499 aa)
     
   
  0.536
TXNDC11
Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (958 aa)
       
      0.518
MOB2
MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L; Belongs to the MOB1/phocein family (268 aa)
           
  0.504
CLDN12
Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins (244 aa)
           
  0.481
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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