node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKAP13 | PRUNE2 | ENSP00000354718 | ENSP00000365908 | A-kinase anchor protein 13; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of R [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | 0.657 |
FYN | PRUNE2 | ENSP00000346671 | ENSP00000365908 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | 0.818 |
FYN | SRC | ENSP00000346671 | ENSP00000362680 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy be [...] | 0.998 |
FYN | YES1 | ENSP00000346671 | ENSP00000462468 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...] | 0.999 |
IMMP2L | PRUNE2 | ENSP00000384966 | ENSP00000365908 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | 0.577 |
KIAA0895 | PRUNE2 | ENSP00000297063 | ENSP00000365908 | Uncharacterized protein KIAA0895; KIAA0895 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | 0.563 |
KIAA0895 | ZNF385D | ENSP00000297063 | ENSP00000281523 | Uncharacterized protein KIAA0895; KIAA0895 | Zinc finger protein 385D | 0.771 |
KIF24 | PRUNE2 | ENSP00000368464 | ENSP00000365908 | Kinesin-like protein KIF24; Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppres [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | 0.557 |
PRUNE2 | AKAP13 | ENSP00000365908 | ENSP00000354718 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | A-kinase anchor protein 13; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of R [...] | 0.657 |
PRUNE2 | FYN | ENSP00000365908 | ENSP00000346671 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | 0.818 |
PRUNE2 | IMMP2L | ENSP00000365908 | ENSP00000384966 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO; Belongs to the peptidase S26 family. IMP2 subfamily | 0.577 |
PRUNE2 | KIAA0895 | ENSP00000365908 | ENSP00000297063 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Uncharacterized protein KIAA0895; KIAA0895 | 0.563 |
PRUNE2 | KIF24 | ENSP00000365908 | ENSP00000368464 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Kinesin-like protein KIF24; Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppres [...] | 0.557 |
PRUNE2 | SPTY2D1 | ENSP00000365908 | ENSP00000337991 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4. Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holli [...] | 0.640 |
PRUNE2 | SRC | ENSP00000365908 | ENSP00000362680 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy be [...] | 0.678 |
PRUNE2 | TTPA | ENSP00000365908 | ENSP00000260116 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Alpha-tocopherol transfer protein; Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity) | 0.748 |
PRUNE2 | YES1 | ENSP00000365908 | ENSP00000462468 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...] | 0.792 |
PRUNE2 | ZNF385D | ENSP00000365908 | ENSP00000281523 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | Zinc finger protein 385D | 0.551 |
SPTY2D1 | PRUNE2 | ENSP00000337991 | ENSP00000365908 | Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4. Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holli [...] | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing | 0.640 |
SRC | FYN | ENSP00000362680 | ENSP00000346671 | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy be [...] | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] | 0.998 |