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  • 11.0 [archived version]
STRINGSTRING
SUGCT SUGCT SP140 SP140 VENTX VENTX FAM91A1 FAM91A1 RAX2 RAX2 DPRX DPRX NANOGNB NANOGNB LEUTX LEUTX PEPD PEPD TPRX1 TPRX1 LBX1 LBX1
"DPRX" - Divergent paired-related homeobox in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
DPRXDivergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes (191 aa)    
Predicted Functional Partners:
LEUTX
PRD class homeoboxes and pseudogenes (168 aa)
      
 
  0.866
TPRX1
Tetra-peptide repeat homeobox protein 1; PRD class homeoboxes and pseudogenes (411 aa)
      
 
  0.852
LBX1
Transcription factor LBX1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord; NKL subclass homeoboxes and pseudogenes (281 aa)
      
 
  0.780
VENTX
Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes (258 aa)
      
 
  0.758
RAX2
Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter; PRD class homeoboxes and pseudogenes (184 aa)
            
  0.749
SP140
Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails; Bromodomain containing (867 aa)
        
 
  0.706
NANOGNB
NANOG neighbor homeobox (188 aa)
            
  0.669
SUGCT
Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate; Belongs to the CaiB/BaiF CoA-transferase family (445 aa)
            
  0.664
FAM91A1
Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family (838 aa)
            
  0.648
PEPD
Xaa-Pro dipeptidase; Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen; Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily (493 aa)
            
  0.643
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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