| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFAP221 | SPAG16 | ENSP00000393222 | ENSP00000332592 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | 0.676 |
| CFAP221 | SPAG17 | ENSP00000393222 | ENSP00000337804 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts | 0.730 |
| CFAP221 | SPAG6 | ENSP00000393222 | ENSP00000365811 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.799 |
| CFAP221 | SPEF2 | ENSP00000393222 | ENSP00000348314 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated | Sperm flagellar protein 2; Required for correct axoneme development | 0.846 |
| DAW1 | SPAG6 | ENSP00000311899 | ENSP00000365811 | Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.904 |
| EFHC1 | FOXJ1 | ENSP00000360107 | ENSP00000323880 | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | 0.515 |
| EFHC1 | SPAG17 | ENSP00000360107 | ENSP00000337804 | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts | 0.405 |
| EFHC1 | SPAG6 | ENSP00000360107 | ENSP00000365811 | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.718 |
| EFHC1 | TEKT1 | ENSP00000360107 | ENSP00000341346 | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family | 0.818 |
| FOXJ1 | EFHC1 | ENSP00000323880 | ENSP00000360107 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing | 0.515 |
| FOXJ1 | SPAG6 | ENSP00000323880 | ENSP00000365811 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.781 |
| FOXJ1 | TEKT1 | ENSP00000323880 | ENSP00000341346 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5’-HWDTGTTTGTTTA-3’ or 5’- KTTTGTTGTTKTW-3’ (where H is not G, W is A or T, D is not C, and K is G or T); Belongs to the FOXJ1 family | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family | 0.567 |
| KPNB1 | SPAG6 | ENSP00000290158 | ENSP00000365811 | Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic [...] | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.726 |
| MEIG1 | SPAG16 | ENSP00000384334 | ENSP00000332592 | Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | 0.992 |
| MEIG1 | SPAG6 | ENSP00000384334 | ENSP00000365811 | Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.935 |
| SPAG16 | CFAP221 | ENSP00000332592 | ENSP00000393222 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated | 0.676 |
| SPAG16 | MEIG1 | ENSP00000332592 | ENSP00000384334 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis | 0.992 |
| SPAG16 | SPAG17 | ENSP00000332592 | ENSP00000337804 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts | 0.842 |
| SPAG16 | SPAG6 | ENSP00000332592 | ENSP00000365811 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.979 |
| SPAG16 | SPEF2 | ENSP00000332592 | ENSP00000348314 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity); WD repeat domain containing | Sperm flagellar protein 2; Required for correct axoneme development | 0.486 |
