| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BOP1 | DDX55 | ENSP00000455106 | ENSP00000238146 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | 0.968 |
| BOP1 | EIF6 | ENSP00000455106 | ENSP00000363574 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] | 0.958 |
| BOP1 | GNL1 | ENSP00000455106 | ENSP00000365806 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster | 0.886 |
| BOP1 | GTPBP4 | ENSP00000455106 | ENSP00000354040 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily | 0.986 |
| BOP1 | NMD3 | ENSP00000455106 | ENSP00000419004 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit | 0.940 |
| BOP1 | PES1 | ENSP00000455106 | ENSP00000346725 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family | 0.999 |
| BOP1 | RPF2 | ENSP00000455106 | ENSP00000402338 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus | 0.971 |
| BOP1 | SDAD1 | ENSP00000455106 | ENSP00000348596 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family | 0.906 |
| CCDC116 | GNL1 | ENSP00000292779 | ENSP00000365806 | Coiled-coil domain containing 116 | Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster | 0.855 |
| CCDC116 | PAPSS1 | ENSP00000292779 | ENSP00000265174 | Coiled-coil domain containing 116 | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Required [...] | 0.865 |
| DDX55 | BOP1 | ENSP00000238146 | ENSP00000455106 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | 0.968 |
| DDX55 | EIF6 | ENSP00000238146 | ENSP00000363574 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] | 0.713 |
| DDX55 | GNL1 | ENSP00000238146 | ENSP00000365806 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster | 0.846 |
| DDX55 | GTPBP4 | ENSP00000238146 | ENSP00000354040 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily | 0.982 |
| DDX55 | NMD3 | ENSP00000238146 | ENSP00000419004 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit | 0.929 |
| DDX55 | PES1 | ENSP00000238146 | ENSP00000346725 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family | 0.949 |
| DDX55 | RPF2 | ENSP00000238146 | ENSP00000402338 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus | 0.975 |
| DDX55 | SDAD1 | ENSP00000238146 | ENSP00000348596 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family | 0.938 |
| EIF6 | BOP1 | ENSP00000363574 | ENSP00000455106 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ERB1 family | 0.958 |
| EIF6 | DDX55 | ENSP00000363574 | ENSP00000238146 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...] | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases | 0.713 |
