node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C9orf64 | GKAP1 | ENSP00000365522 | ENSP00000365550 | Queuosine salvage protein; Involved in salvaging queuosine | G kinase anchoring protein 1; Belongs to the GKAP1 family | 0.558 |
C9orf64 | KIF27 | ENSP00000365522 | ENSP00000297814 | Queuosine salvage protein; Involved in salvaging queuosine | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins | 0.517 |
ECT2 | GKAP1 | ENSP00000376457 | ENSP00000365550 | Protein ECT2; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role i [...] | G kinase anchoring protein 1; Belongs to the GKAP1 family | 0.564 |
GKAP1 | C9orf64 | ENSP00000365550 | ENSP00000365522 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Queuosine salvage protein; Involved in salvaging queuosine | 0.558 |
GKAP1 | ECT2 | ENSP00000365550 | ENSP00000376457 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Protein ECT2; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role i [...] | 0.564 |
GKAP1 | HOMER1 | ENSP00000365550 | ENSP00000334382 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabo [...] | 0.719 |
GKAP1 | ITGA2B | ENSP00000365550 | ENSP00000262407 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Integrin alpha-IIb; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface; CD molecules | 0.531 |
GKAP1 | KIF27 | ENSP00000365550 | ENSP00000297814 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins | 0.583 |
GKAP1 | LHFPL3 | ENSP00000365550 | ENSP00000393128 | G kinase anchoring protein 1; Belongs to the GKAP1 family | LHFPL tetraspan subfamily member 3 | 0.514 |
GKAP1 | PRKG1 | ENSP00000365550 | ENSP00000363092 | G kinase anchoring protein 1; Belongs to the GKAP1 family | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] | 0.971 |
GKAP1 | SETD2 | ENSP00000365550 | ENSP00000386759 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates ’Lys-36’ of histone H3 (H3K36me3) using dimethylated ’Lys-36’ (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recr [...] | 0.519 |
GKAP1 | TBCEL | ENSP00000365550 | ENSP00000403925 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability | 0.588 |
GKAP1 | TEFM | ENSP00000365550 | ENSP00000462963 | G kinase anchoring protein 1; Belongs to the GKAP1 family | Transcription elongation factor, mitochondrial; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery; Belongs to the TEFM family | 0.514 |
HOMER1 | GKAP1 | ENSP00000334382 | ENSP00000365550 | Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabo [...] | G kinase anchoring protein 1; Belongs to the GKAP1 family | 0.719 |
ITGA2B | GKAP1 | ENSP00000262407 | ENSP00000365550 | Integrin alpha-IIb; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface; CD molecules | G kinase anchoring protein 1; Belongs to the GKAP1 family | 0.531 |
KIF27 | C9orf64 | ENSP00000297814 | ENSP00000365522 | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins | Queuosine salvage protein; Involved in salvaging queuosine | 0.517 |
KIF27 | GKAP1 | ENSP00000297814 | ENSP00000365550 | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins | G kinase anchoring protein 1; Belongs to the GKAP1 family | 0.583 |
KIF27 | LHFPL3 | ENSP00000297814 | ENSP00000393128 | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins | LHFPL tetraspan subfamily member 3 | 0.531 |
KIF27 | TBCEL | ENSP00000297814 | ENSP00000403925 | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability | 0.583 |
LHFPL3 | GKAP1 | ENSP00000393128 | ENSP00000365550 | LHFPL tetraspan subfamily member 3 | G kinase anchoring protein 1; Belongs to the GKAP1 family | 0.514 |