| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C9orf64 | DTYMK | ENSP00000365522 | ENSP00000304802 | Queuosine salvage protein; Involved in salvaging queuosine | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.633 |
| C9orf64 | FAM96A | ENSP00000365522 | ENSP00000300030 | Queuosine salvage protein; Involved in salvaging queuosine | MIP18 family protein FAM96A; May play a role in chromosome segregation through establishment of sister chromatid cohesion; Belongs to the MIP18 family | 0.639 |
| C9orf64 | HMGN4 | ENSP00000365522 | ENSP00000366798 | Queuosine salvage protein; Involved in salvaging queuosine | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family | 0.685 |
| C9orf64 | IMP4 | ENSP00000365522 | ENSP00000259239 | Queuosine salvage protein; Involved in salvaging queuosine | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; MPP10 subcomplex | 0.589 |
| C9orf64 | MCM5 | ENSP00000365522 | ENSP00000216122 | Queuosine salvage protein; Involved in salvaging queuosine | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.664 |
| C9orf64 | MCTS1 | ENSP00000365522 | ENSP00000360365 | Queuosine salvage protein; Involved in salvaging queuosine | Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] | 0.771 |
| C9orf64 | PCNA | ENSP00000365522 | ENSP00000368458 | Queuosine salvage protein; Involved in salvaging queuosine | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.666 |
| C9orf64 | QTRT1 | ENSP00000365522 | ENSP00000250237 | Queuosine salvage protein; Involved in salvaging queuosine | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1’ of nucleotide 34 to detach the guanine base from the RNA, formi [...] | 0.677 |
| C9orf64 | RNASEH2A | ENSP00000365522 | ENSP00000221486 | Queuosine salvage protein; Involved in salvaging queuosine | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes; Belongs to the RNase HII family. Eukaryotic subfamily | 0.659 |
| C9orf64 | WDR26 | ENSP00000365522 | ENSP00000408108 | Queuosine salvage protein; Involved in salvaging queuosine | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.685 |
| DTYMK | C9orf64 | ENSP00000304802 | ENSP00000365522 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | Queuosine salvage protein; Involved in salvaging queuosine | 0.633 |
| DTYMK | MCM5 | ENSP00000304802 | ENSP00000216122 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.519 |
| DTYMK | PCNA | ENSP00000304802 | ENSP00000368458 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.554 |
| DTYMK | RNASEH2A | ENSP00000304802 | ENSP00000221486 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA-RNA duplexes; Belongs to the RNase HII family. Eukaryotic subfamily | 0.601 |
| FAM96A | C9orf64 | ENSP00000300030 | ENSP00000365522 | MIP18 family protein FAM96A; May play a role in chromosome segregation through establishment of sister chromatid cohesion; Belongs to the MIP18 family | Queuosine salvage protein; Involved in salvaging queuosine | 0.639 |
| HMGN4 | C9orf64 | ENSP00000366798 | ENSP00000365522 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family | Queuosine salvage protein; Involved in salvaging queuosine | 0.685 |
| HMGN4 | WDR26 | ENSP00000366798 | ENSP00000408108 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta-gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration. [...] | 0.556 |
| IMP4 | C9orf64 | ENSP00000259239 | ENSP00000365522 | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; MPP10 subcomplex | Queuosine salvage protein; Involved in salvaging queuosine | 0.589 |
| MCM5 | C9orf64 | ENSP00000216122 | ENSP00000365522 | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Queuosine salvage protein; Involved in salvaging queuosine | 0.664 |
| MCM5 | DTYMK | ENSP00000216122 | ENSP00000304802 | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family | 0.519 |
