node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IRF3 | PLP2 | ENSP00000471896 | ENSP00000365505 | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive [...] | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | 0.618 |
IRF3 | SH2D3C | ENSP00000471896 | ENSP00000317817 | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive [...] | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity); NSP adaptor proteins | 0.418 |
PDCL2 | PLP2 | ENSP00000295645 | ENSP00000365505 | Phosducin-like protein 2; May play a role in germ cell maturation | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | 0.906 |
PDCL2 | TCP1 | ENSP00000295645 | ENSP00000317334 | Phosducin-like protein 2; May play a role in germ cell maturation | T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family | 0.416 |
PDCL3 | PLP2 | ENSP00000264254 | ENSP00000365505 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | 0.808 |
PDCL3 | TCP1 | ENSP00000264254 | ENSP00000317334 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family | 0.857 |
PDCL3 | TUBB | ENSP00000264254 | ENSP00000339001 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins | 0.668 |
PDCL3 | TUBB2A | ENSP00000264254 | ENSP00000369703 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | Tubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity); Tubulins | 0.666 |
PLP1 | PLP2 | ENSP00000481006 | ENSP00000365505 | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | 0.947 |
PLP2 | IRF3 | ENSP00000365505 | ENSP00000471896 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive [...] | 0.618 |
PLP2 | PDCL2 | ENSP00000365505 | ENSP00000295645 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Phosducin-like protein 2; May play a role in germ cell maturation | 0.906 |
PLP2 | PDCL3 | ENSP00000365505 | ENSP00000264254 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination; Belongs to the phosducin family | 0.808 |
PLP2 | PLP1 | ENSP00000365505 | ENSP00000481006 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family | 0.947 |
PLP2 | PTCD3 | ENSP00000365505 | ENSP00000254630 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation | 0.787 |
PLP2 | SH2D3C | ENSP00000365505 | ENSP00000317817 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity); NSP adaptor proteins | 0.589 |
PLP2 | SLC12A4 | ENSP00000365505 | ENSP00000395983 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Solute carrier family 12 member 4; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity; Belongs to the SLC12A transporter family | 0.820 |
PLP2 | TCP1 | ENSP00000365505 | ENSP00000317334 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family | 0.621 |
PLP2 | TUBB | ENSP00000365505 | ENSP00000339001 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Tubulins | 0.640 |
PLP2 | TUBB2A | ENSP00000365505 | ENSP00000369703 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | Tubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity); Tubulins | 0.640 |
PTCD3 | PLP2 | ENSP00000254630 | ENSP00000365505 | Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium | 0.787 |