node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MUC12 | MUC13 | ENSP00000441929 | ENSP00000485028 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | 0.979 |
MUC12 | MUC15 | ENSP00000441929 | ENSP00000416753 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins | 0.978 |
MUC12 | MUC16 | ENSP00000441929 | ENSP00000381008 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces; Mucins | 0.972 |
MUC12 | MUC17 | ENSP00000441929 | ENSP00000302716 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces; Mucins | 0.942 |
MUC12 | MUC20 | ENSP00000441929 | ENSP00000414350 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression; Mucins | 0.977 |
MUC12 | MUC21 | ENSP00000441929 | ENSP00000365473 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-21; Mucin 21, cell surface associated; Mucins | 0.969 |
MUC12 | MUC3A | ENSP00000441929 | ENSP00000368771 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-3A; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling; Mucins | 0.940 |
MUC12 | MUC4 | ENSP00000441929 | ENSP00000417498 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-4; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 ’Tyr-1248’. In [...] | 0.938 |
MUC12 | MUC6 | ENSP00000441929 | ENSP00000406861 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-6; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis; Mucins | 0.972 |
MUC12 | MUC7 | ENSP00000441929 | ENSP00000407422 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins | 0.972 |
MUC13 | MUC12 | ENSP00000485028 | ENSP00000441929 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in intestinal epithelium; Mucins | 0.979 |
MUC13 | MUC15 | ENSP00000485028 | ENSP00000416753 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins | 0.979 |
MUC13 | MUC16 | ENSP00000485028 | ENSP00000381008 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces; Mucins | 0.972 |
MUC13 | MUC17 | ENSP00000485028 | ENSP00000302716 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces; Mucins | 0.980 |
MUC13 | MUC20 | ENSP00000485028 | ENSP00000414350 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression; Mucins | 0.979 |
MUC13 | MUC21 | ENSP00000485028 | ENSP00000365473 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-21; Mucin 21, cell surface associated; Mucins | 0.967 |
MUC13 | MUC3A | ENSP00000485028 | ENSP00000368771 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-3A; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling; Mucins | 0.974 |
MUC13 | MUC4 | ENSP00000485028 | ENSP00000417498 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-4; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 ’Tyr-1248’. In [...] | 0.979 |
MUC13 | MUC6 | ENSP00000485028 | ENSP00000406861 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-6; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis; Mucins | 0.971 |
MUC13 | MUC7 | ENSP00000485028 | ENSP00000407422 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins | 0.968 |