node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | GAD1 | ENSP00000379845 | ENSP00000350928 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.981 |
ABAT | GAD2 | ENSP00000379845 | ENSP00000365437 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.982 |
ABAT | GLUL | ENSP00000379845 | ENSP00000307900 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Glutamine synthetase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts; Belongs to the glutamine synthetase family | 0.961 |
GAD1 | ABAT | ENSP00000350928 | ENSP00000379845 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.981 |
GAD1 | GAD2 | ENSP00000350928 | ENSP00000365437 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutamate decarboxylase 2; Catalyzes the production of GABA | 0.956 |
GAD1 | GLS2 | ENSP00000350928 | ENSP00000310447 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Ankyrin repeat domain containing | 0.941 |
GAD1 | GLUL | ENSP00000350928 | ENSP00000307900 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Glutamine synthetase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts; Belongs to the glutamine synthetase family | 0.948 |
GAD1 | PTPRN | ENSP00000350928 | ENSP00000295718 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation [...] | 0.454 |
GAD1 | SLC32A1 | ENSP00000350928 | ENSP00000217420 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.999 |
GAD1 | SNAP25 | ENSP00000350928 | ENSP00000254976 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.959 |
GAD1 | STX1A | ENSP00000350928 | ENSP00000222812 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm; Syntaxins | 0.926 |
GAD1 | SYT1 | ENSP00000350928 | ENSP00000261205 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.949 |
GAD1 | VAMP2 | ENSP00000350928 | ENSP00000314214 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1; Belongs to the synaptobrevin family | 0.923 |
GAD2 | ABAT | ENSP00000365437 | ENSP00000379845 | Glutamate decarboxylase 2; Catalyzes the production of GABA | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.982 |
GAD2 | GAD1 | ENSP00000365437 | ENSP00000350928 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family | 0.956 |
GAD2 | GLS2 | ENSP00000365437 | ENSP00000310447 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation; Ankyrin repeat domain containing | 0.937 |
GAD2 | GLUL | ENSP00000365437 | ENSP00000307900 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Glutamine synthetase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts; Belongs to the glutamine synthetase family | 0.949 |
GAD2 | PTPRN | ENSP00000365437 | ENSP00000295718 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation [...] | 0.949 |
GAD2 | SLC32A1 | ENSP00000365437 | ENSP00000217420 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers | 0.994 |
GAD2 | SNAP25 | ENSP00000365437 | ENSP00000254976 | Glutamate decarboxylase 2; Catalyzes the production of GABA | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.967 |