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  • 11.0 [archived version]
STRINGSTRING
LMAN1L LMAN1L CCDC85C CCDC85C C11orf21 C11orf21 KIAA1211L KIAA1211L C19orf52 C19orf52 R3HCC1 R3HCC1 ZNF549 ZNF549 PNPLA7 PNPLA7 WFDC10B WFDC10B TRIM28 TRIM28 ATXN7L1 ATXN7L1
"ZNF549" - Zinc finger protein 549 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
ZNF549Zinc finger protein 549; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (640 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.920
WFDC10B
Protein WFDC10B; WAP four-disulfide core domain containing (89 aa)
           
  0.556
R3HCC1
R3H domain and coiled-coil containing 1 (253 aa)
           
  0.531
KIAA1211L
Uncharacterized protein KIAA1211-like; KIAA1211 like (962 aa)
           
  0.530
C19orf52
Mitochondrial import inner membrane translocase subunit Tim29; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40 (260 aa)
           
  0.511
CCDC85C
Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia (419 aa)
           
  0.474
C11orf21
Uncharacterized protein C11orf21; Chromosome 11 open reading frame 21 (178 aa)
           
  0.473
LMAN1L
Protein ERGIC-53-like; Lectin, mannose binding 1 like (526 aa)
           
  0.473
ATXN7L1
Ataxin-7-like protein 1; Ataxin 7 like 1 (861 aa)
       
 
  0.466
PNPLA7
Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy; Patatin like phospholipase domain containing (1342 aa)
     
 
  0.462
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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