| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APEX1 | SHROOM4 | ENSP00000216714 | ENSP00000365188 | DNA-(apurinic or apyrimidinic site) lyase; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’-deoxyribo [...] | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.718 |
| IQSEC2 | SHROOM4 | ENSP00000379712 | ENSP00000365188 | IQ motif and SEC7 domain-containing protein 2; Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins; X-linked mental retardation | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.479 |
| MPP7 | SHROOM4 | ENSP00000337907 | ENSP00000365188 | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact; Belongs to the MAGUK family | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.473 |
| MYH14 | MYH7B | ENSP00000470298 | ENSP00000262873 | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes | Myosin-7B; Involved in muscle contraction; Myosin heavy chains | 0.566 |
| MYH14 | SHROOM4 | ENSP00000470298 | ENSP00000365188 | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.648 |
| MYH7B | MYH14 | ENSP00000262873 | ENSP00000470298 | Myosin-7B; Involved in muscle contraction; Myosin heavy chains | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes | 0.566 |
| MYH7B | SHROOM4 | ENSP00000262873 | ENSP00000365188 | Myosin-7B; Involved in muscle contraction; Myosin heavy chains | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.641 |
| PBDC1 | SHROOM4 | ENSP00000362456 | ENSP00000365188 | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.510 |
| PQBP1 | SHROOM4 | ENSP00000218224 | ENSP00000365188 | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | 0.510 |
| PQBP1 | ZNF41 | ENSP00000218224 | ENSP00000366265 | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | Zinc finger protein 41; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.504 |
| SHROOM4 | APEX1 | ENSP00000365188 | ENSP00000216714 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | DNA-(apurinic or apyrimidinic site) lyase; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5’-deoxyribo [...] | 0.718 |
| SHROOM4 | IQSEC2 | ENSP00000365188 | ENSP00000379712 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | IQ motif and SEC7 domain-containing protein 2; Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins; X-linked mental retardation | 0.479 |
| SHROOM4 | MPP7 | ENSP00000365188 | ENSP00000337907 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact; Belongs to the MAGUK family | 0.473 |
| SHROOM4 | MYH14 | ENSP00000365188 | ENSP00000470298 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes | 0.648 |
| SHROOM4 | MYH7B | ENSP00000365188 | ENSP00000262873 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Myosin-7B; Involved in muscle contraction; Myosin heavy chains | 0.641 |
| SHROOM4 | PBDC1 | ENSP00000365188 | ENSP00000362456 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family | 0.510 |
| SHROOM4 | PQBP1 | ENSP00000365188 | ENSP00000218224 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-in [...] | 0.510 |
| SHROOM4 | SULT1B1 | ENSP00000365188 | ENSP00000308770 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Sulfotransferase family cytosolic 1B member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3’-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine; Sulf [...] | 0.480 |
| SHROOM4 | TOMM40 | ENSP00000365188 | ENSP00000410339 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria; Belongs to the Tom40 family | 0.519 |
| SHROOM4 | ZNF41 | ENSP00000365188 | ENSP00000366265 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II (By similarity); Belongs to the shroom family | Zinc finger protein 41; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.473 |
