CTRC protein (human) - STRING database

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Score

CTRC

Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)

Predicted Functional Partners:

CPA1

0.952

PRSS1

0.941

PLAUR

0.909

SPINK1

0.896

CPB1

0.877

CELA3B

0.819

CELA3A

0.779

CPA2

0.718

HTRA1

0.716

CPB2

0.687

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CELA3A	CPA1	ENSP00000290122	ENSP00000011292	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	0.969
CELA3A	CPA2	ENSP00000290122	ENSP00000222481	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	M14 carboxypeptidases	0.831
CELA3A	CPB1	ENSP00000290122	ENSP00000417222	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.877
CELA3A	CPB2	ENSP00000290122	ENSP00000181383	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family	0.425
CELA3A	CTRC	ENSP00000290122	ENSP00000365116	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity	0.779
CELA3A	PRSS1	ENSP00000290122	ENSP00000308720	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.494
CELA3B	CPA1	ENSP00000338369	ENSP00000011292	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	0.979
CELA3B	CPA2	ENSP00000338369	ENSP00000222481	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	M14 carboxypeptidases	0.690
CELA3B	CPB1	ENSP00000338369	ENSP00000417222	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.913
CELA3B	CPB2	ENSP00000338369	ENSP00000181383	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family	0.485
CELA3B	CTRC	ENSP00000338369	ENSP00000365116	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity	0.819
CELA3B	SPINK1	ENSP00000338369	ENSP00000296695	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type	0.614
CPA1	CELA3A	ENSP00000011292	ENSP00000290122	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	0.969
CPA1	CELA3B	ENSP00000011292	ENSP00000338369	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity	0.979
CPA1	CPA2	ENSP00000011292	ENSP00000222481	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	M14 carboxypeptidases	0.867
CPA1	CPB1	ENSP00000011292	ENSP00000417222	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.844
CPA1	CTRC	ENSP00000011292	ENSP00000365116	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity	0.952
CPA1	PRSS1	ENSP00000011292	ENSP00000308720	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two- chain form against all of these substrates; Belongs to the peptidase S1 family	0.778
CPA1	SPINK1	ENSP00000011292	ENSP00000296695	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type	0.685
CPA2	CELA3A	ENSP00000222481	ENSP00000290122	M14 carboxypeptidases	Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity	0.831

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