LY6G6F protein (human) - STRING database

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LY6G6F

Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing (297 aa)

Predicted Functional Partners:

GRB7

0.815

LY6G6E

0.696

LY6G5B

0.686

C6orf25

0.670

GRB2

0.608

ENSG00000204422

0.582

C6orf1

0.574

LY6G5C

0.559

LY6G6C

0.521

PRR3

0.520

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf1	LY6G5B	ENSP00000417604	ENSP00000365024	Uncharacterized protein SMIM29; Chromosome 6 open reading frame 1	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	0.531
C6orf1	LY6G6F	ENSP00000417604	ENSP00000364992	Uncharacterized protein SMIM29; Chromosome 6 open reading frame 1	Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing	0.574
C6orf25	LY6G5B	ENSP00000364964	ENSP00000365024	Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	0.473
C6orf25	LY6G5C	ENSP00000364964	ENSP00000372724	Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner	Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing	0.428
C6orf25	LY6G6C	ENSP00000364964	ENSP00000364978	Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner	Lymphocyte antigen 6 family member G6C; LY6/PLAUR domain containing	0.669
C6orf25	LY6G6E	ENSP00000364964	ENSP00000372910	Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner	Lymphocyte antigen 6 family member G6E; LY6/PLAUR domain containing	0.560
C6orf25	LY6G6F	ENSP00000364964	ENSP00000364992	Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner	Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing	0.670
ENSG00000204422	LY6G5B	ENSP00000475702	ENSP00000365024	Lymphocyte antigen 6 family member G6E	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	0.687
ENSG00000204422	LY6G5C	ENSP00000475702	ENSP00000372724	Lymphocyte antigen 6 family member G6E	Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing	0.615
ENSG00000204422	LY6G6C	ENSP00000475702	ENSP00000364978	Lymphocyte antigen 6 family member G6E	Lymphocyte antigen 6 family member G6C; LY6/PLAUR domain containing	0.739
ENSG00000204422	LY6G6F	ENSP00000475702	ENSP00000364992	Lymphocyte antigen 6 family member G6E	Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing	0.582
GRB2	GRB7	ENSP00000376345	ENSP00000403459	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing	Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5’UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...]	0.853
GRB2	LY6G6F	ENSP00000376345	ENSP00000364992	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing	Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing	0.608
GRB7	GRB2	ENSP00000403459	ENSP00000376345	Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5’UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...]	Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing	0.853
GRB7	LY6G6F	ENSP00000403459	ENSP00000364992	Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5’UTR of target mRNA molecules and represses translation of target mRNA species, when not phos [...]	Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing	0.815
LY6G5B	C6orf1	ENSP00000365024	ENSP00000417604	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	Uncharacterized protein SMIM29; Chromosome 6 open reading frame 1	0.531
LY6G5B	C6orf25	ENSP00000365024	ENSP00000364964	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6-FcRgamma signaling. Appears to operate in a calcium-independent manner	0.473
LY6G5B	ENSG00000204422	ENSP00000365024	ENSP00000475702	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	Lymphocyte antigen 6 family member G6E	0.687
LY6G5B	LY6G5C	ENSP00000365024	ENSP00000372724	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing	0.680
LY6G5B	LY6G6C	ENSP00000365024	ENSP00000364978	Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing	Lymphocyte antigen 6 family member G6C; LY6/PLAUR domain containing	0.733

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