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CARD17 - Caspase recruitment domain-containing protein 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation; Caspase recruitment domain containing
[a.k.a. INCA, Inhibitory caspase recruitment domain protein, Caspase recruitment domain containing,
CASP1 - Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family
[a.k.a. IL1BC, IL1BCE, AAH62327.1,
© STRING Consortium 2020
SIB - Swiss Institute of Bioinformatics
CPR - Novo Nordisk Foundation Center Protein Research
EMBL - European Molecular Biology Laboratory
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