FAM131C protein (human) - STRING database

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FAM131C

Protein FAM131C; Family with sequence similarity 131 member C (280 aa)

Predicted Functional Partners:

STK32A

0.813

HPCAL4

0.751

STK32B

0.734

C22orf42

0.710

DRICH1

0.673

AIFM3

0.670

FBXL7

0.653

P2RX5

0.604

PPM1B

0.538

MCC

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM3	C22orf42	ENSP00000382120	ENSP00000371529	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	0.473
AIFM3	DRICH1	ENSP00000382120	ENSP00000316137	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	Aspartate-rich protein 1; Aspartate rich 1	0.440
AIFM3	FAM131C	ENSP00000382120	ENSP00000364814	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	Protein FAM131C; Family with sequence similarity 131 member C	0.670
AIFM3	FBXL7	ENSP00000382120	ENSP00000423630	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins	0.452
AIFM3	P2RX5	ENSP00000382120	ENSP00000225328	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	P2X purinoceptor 5; Receptor for ATP that acts as a ligand-gated ion channel; Minor histocompatibility antigens	0.473
AIFM3	PPM1B	ENSP00000382120	ENSP00000282412	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at ’Ser- 172’. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family	0.440
AIFM3	STK32A	ENSP00000382120	ENSP00000381535	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	Serine/threonine kinase 32A	0.621
AIFM3	STK32B	ENSP00000382120	ENSP00000282908	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	Serine/threonine kinase 32B	0.459
C22orf42	AIFM3	ENSP00000371529	ENSP00000382120	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	0.473
C22orf42	DRICH1	ENSP00000371529	ENSP00000316137	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Aspartate-rich protein 1; Aspartate rich 1	0.669
C22orf42	FAM131C	ENSP00000371529	ENSP00000364814	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Protein FAM131C; Family with sequence similarity 131 member C	0.710
C22orf42	FBXL7	ENSP00000371529	ENSP00000423630	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins	0.473
C22orf42	MCC	ENSP00000371529	ENSP00000386227	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and n [...]	0.475
C22orf42	PPM1B	ENSP00000371529	ENSP00000282412	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at ’Ser- 172’. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family	0.416
C22orf42	STK32A	ENSP00000371529	ENSP00000381535	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Serine/threonine kinase 32A	0.585
C22orf42	STK32B	ENSP00000371529	ENSP00000282908	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	Serine/threonine kinase 32B	0.541
DRICH1	AIFM3	ENSP00000316137	ENSP00000382120	Aspartate-rich protein 1; Aspartate rich 1	Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential	0.440
DRICH1	C22orf42	ENSP00000316137	ENSP00000371529	Aspartate-rich protein 1; Aspartate rich 1	Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42	0.669
DRICH1	FAM131C	ENSP00000316137	ENSP00000364814	Aspartate-rich protein 1; Aspartate rich 1	Protein FAM131C; Family with sequence similarity 131 member C	0.673
DRICH1	FBXL7	ENSP00000316137	ENSP00000423630	Aspartate-rich protein 1; Aspartate rich 1	F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest; F-box and leucine rich repeat proteins	0.429

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