| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARSA | CTSA | ENSP00000216124 | ENSP00000361562 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.937 |
| ARSA | CTSD | ENSP00000216124 | ENSP00000236671 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.467 |
| ARSA | ELANE | ENSP00000216124 | ENSP00000466090 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis | 0.905 |
| ARSA | GLA | ENSP00000216124 | ENSP00000218516 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.946 |
| ARSA | GLB1 | ENSP00000216124 | ENSP00000306920 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.952 |
| ARSA | NEU1 | ENSP00000216124 | ENSP00000364782 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage | 0.923 |
| CHIT1 | CTSD | ENSP00000356198 | ENSP00000236671 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.922 |
| CHIT1 | CTSZ | ENSP00000356198 | ENSP00000217131 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity; Cathepsins | 0.905 |
| CHIT1 | ELANE | ENSP00000356198 | ENSP00000466090 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis | 0.905 |
| CHIT1 | GLA | ENSP00000356198 | ENSP00000218516 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.414 |
| CHIT1 | LRG1 | ENSP00000356198 | ENSP00000302621 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Leucine rich alpha-2-glycoprotein 1 | 0.903 |
| CHIT1 | NEU1 | ENSP00000356198 | ENSP00000364782 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage | 0.909 |
| CHIT1 | OSCAR | ENSP00000356198 | ENSP00000479089 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily | Osteoclast-associated immunoglobulin-like receptor; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation; Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family | 0.903 |
| CTSA | ARSA | ENSP00000361562 | ENSP00000216124 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.937 |
| CTSA | CTSD | ENSP00000361562 | ENSP00000236671 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease; Cathepsins | 0.891 |
| CTSA | CTSZ | ENSP00000361562 | ENSP00000217131 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity; Cathepsins | 0.578 |
| CTSA | ELANE | ENSP00000361562 | ENSP00000466090 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis | 0.908 |
| CTSA | GLA | ENSP00000361562 | ENSP00000218516 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.967 |
| CTSA | GLB1 | ENSP00000361562 | ENSP00000306920 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.993 |
| CTSA | NEU1 | ENSP00000361562 | ENSP00000364782 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage | 0.987 |
