node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HAPLN1 | LAYN | ENSP00000274341 | ENSP00000364765 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.618 |
HMMR | LAYN | ENSP00000377492 | ENSP00000364765 | Hyaluronan mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity); CD molecules | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.575 |
LAYN | HAPLN1 | ENSP00000364765 | ENSP00000274341 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing | 0.618 |
LAYN | HMMR | ENSP00000364765 | ENSP00000377492 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Hyaluronan mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity); CD molecules | 0.575 |
LAYN | MAGEH1 | ENSP00000364765 | ENSP00000343706 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Melanoma-associated antigen H1; MAGE family member H1 | 0.503 |
LAYN | NF2 | ENSP00000364765 | ENSP00000344666 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] | 0.649 |
LAYN | PNRC1 | ENSP00000364765 | ENSP00000336931 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | 0.492 |
LAYN | PRSS12 | ENSP00000364765 | ENSP00000296498 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 family | 0.533 |
LAYN | SMOC1 | ENSP00000364765 | ENSP00000355110 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation; SPARC family | 0.513 |
LAYN | TLE2 | ENSP00000364765 | ENSP00000466542 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Transducin-like enhancer protein 2; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); Belongs to the WD repeat Groucho/TLE family | 0.538 |
LAYN | TLN1 | ENSP00000364765 | ENSP00000316029 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity); FERM domain containing | 0.894 |
LAYN | TLN2 | ENSP00000364765 | ENSP00000453508 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | Talin-2; As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity); FERM domain containing | 0.862 |
MAGEH1 | LAYN | ENSP00000343706 | ENSP00000364765 | Melanoma-associated antigen H1; MAGE family member H1 | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.503 |
NF2 | LAYN | ENSP00000344666 | ENSP00000364765 | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.649 |
PNRC1 | LAYN | ENSP00000336931 | ENSP00000364765 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.492 |
PRSS12 | LAYN | ENSP00000296498 | ENSP00000364765 | Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 family | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.533 |
PRSS12 | SMOC1 | ENSP00000296498 | ENSP00000355110 | Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 family | SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation; SPARC family | 0.470 |
SMOC1 | LAYN | ENSP00000355110 | ENSP00000364765 | SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation; SPARC family | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.513 |
SMOC1 | PRSS12 | ENSP00000355110 | ENSP00000296498 | SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation; SPARC family | Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 family | 0.470 |
TLE2 | LAYN | ENSP00000466542 | ENSP00000364765 | Transducin-like enhancer protein 2; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); Belongs to the WD repeat Groucho/TLE family | Layilin; Receptor for hyaluronate; C-type lectin domain containing | 0.538 |