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MFAP4 MFAP4 MFAP1 MFAP1 ELN ELN EFEMP2 EFEMP2 LOXL1 LOXL1 FBLN1 FBLN1 MFAP2 MFAP2 FBLN5 FBLN5 FBN2 FBN2 FBN1 FBN1 MFAP3 MFAP3
"MFAP2" - Microfibrillar-associated protein 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MFAP2Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family (183 aa)    
Predicted Functional Partners:
FBN1
Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] (2871 aa)
     
  0.985
ELN
Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity) (786 aa)
     
  0.983
MFAP1
Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex (439 aa)
         
  0.979
FBN2
Fibrillin-2; Fibrillin-2- Fibrillins are structural components of 10- 12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively; Belongs to the fibrillin family (2912 aa)
     
  0.979
MFAP3
Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils; I-set domain containing (362 aa)
         
  0.979
FBLN5
Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN; Belongs to the fibulin family (448 aa)
     
 
  0.960
EFEMP2
EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family (443 aa)
     
 
  0.956
FBLN1
Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a signi [...] (703 aa)
     
 
  0.956
LOXL1
Lysyl oxidase homolog 1; Active on elastin and collagen substrates (574 aa)
     
 
  0.956
MFAP4
Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance; Fibrinogen C domain containing (279 aa)
     
 
  0.955
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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