• Version:
  • 11.0 [archived version]
STRINGSTRING
VARS VARS ABHD16A ABHD16A GPANK1 GPANK1 PRRC2A PRRC2A EHMT2 EHMT2 DDAH1 DDAH1 ZBTB12 ZBTB12 SKIV2L SKIV2L SPTB SPTB PRRT1 PRRT1 CTNNBL1 CTNNBL1
"ZBTB12" - Zinc finger and BTB domain-containing protein 12 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZBTB12Zinc finger and BTB domain-containing protein 12; May be involved in transcriptional regulation; BTB domain containing (459 aa)    
Predicted Functional Partners:
PRRC2A
Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing (2157 aa)
     
   
  0.819
GPANK1
G-patch domain and ankyrin repeats 1 (356 aa)
           
  0.804
CTNNBL1
Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis; Armadillo-like helical domain containing (563 aa)
       
      0.764
ABHD16A
Protein ABHD16A; Abhydrolase domain containing 16A (558 aa)
           
  0.755
PRRT1
Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family (306 aa)
     
   
  0.737
SKIV2L
Helicase SKI2W; Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C); Belongs to the helicase family. SKI2 subfamily (1246 aa)
     
 
  0.715
DDAH1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (285 aa)
           
  0.663
SPTB
Spectrin beta chain, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane; Pleckstrin homology domain containing (2328 aa)
       
      0.625
EHMT2
Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates ’Lys-9’ of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of ’Lys-56’ of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates ’Lys-27’ of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltr [...] (1233 aa)
     
 
  0.603
VARS
Valine--tRNA ligase; Aminoacyl tRNA synthetases, Class I (1264 aa)
     
 
  0.600
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]