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  • 11.0 [archived version]
STRINGSTRING
C19orf45 C19orf45 OR2W1 OR2W1 BPIFA1 BPIFA1 PTCRA PTCRA BPIFB1 BPIFB1 BPIFB3 BPIFB3 OR5I1 OR5I1 BPIFA2 BPIFA2 BPIFA3 BPIFA3 TEX261 TEX261 TTC16 TTC16
"BPIFB3" - BPI fold-containing family B member 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
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Cooccurence
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[Homology]
Score
BPIFB3BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); BPI fold containing (476 aa)    
Predicted Functional Partners:
BPIFA1
BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...] (256 aa)
     
 
  0.858
BPIFA3
BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (254 aa)
     
   
  0.771
BPIFB1
BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (484 aa)
           
  0.731
OR5I1
Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 (314 aa)
           
  0.683
BPIFA2
BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (249 aa)
     
   
  0.677
OR2W1
Olfactory receptor 2W1; Odorant receptor; Olfactory receptors, family 2 (320 aa)
           
  0.673
TTC16
Tetratricopeptide repeat domain containing (873 aa)
           
  0.633
PTCRA
Pre T-cell antigen receptor alpha; The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development (296 aa)
           
  0.605
TEX261
Protein TEX261; Testis expressed 261 (196 aa)
           
  0.567
C19orf45
Testis-expressed protein 45; Chromosome 19 open reading frame 45 (505 aa)
           
  0.559
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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