node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGXT2 | PADI1 | ENSP00000231420 | ENSP00000364620 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.494 |
AGXT2 | SPAG8 | ENSP00000231420 | ENSP00000340982 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.490 |
AGXT2 | TMEM35 | ENSP00000231420 | ENSP00000362021 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth | 0.554 |
CRACR2B | PADI1 | ENSP00000435299 | ENSP00000364620 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.565 |
DOCK1 | PADI1 | ENSP00000280333 | ENSP00000364620 | Dedicator of cytokinesis protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.522 |
FLG | IVL | ENSP00000357789 | ENSP00000357753 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | 0.994 |
FLG | PADI1 | ENSP00000357789 | ENSP00000364620 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.581 |
FLG | TCHH | ENSP00000357789 | ENSP00000480484 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation; EF-hand domain containing | 0.936 |
IVL | FLG | ENSP00000357753 | ENSP00000357789 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing | 0.994 |
IVL | PADI1 | ENSP00000357753 | ENSP00000364620 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | 0.560 |
IVL | TCHH | ENSP00000357753 | ENSP00000480484 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation; EF-hand domain containing | 0.974 |
PADI1 | AGXT2 | ENSP00000364620 | ENSP00000231420 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family | 0.494 |
PADI1 | CRACR2B | ENSP00000364620 | ENSP00000435299 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing | 0.565 |
PADI1 | DOCK1 | ENSP00000364620 | ENSP00000280333 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Dedicator of cytokinesis protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 | 0.522 |
PADI1 | FLG | ENSP00000364620 | ENSP00000357789 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain containing | 0.581 |
PADI1 | IVL | ENSP00000364620 | ENSP00000357753 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family | 0.560 |
PADI1 | SPAG8 | ENSP00000364620 | ENSP00000340982 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9 [...] | 0.499 |
PADI1 | STAP2 | ENSP00000364620 | ENSP00000468927 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Signal transducing adaptor family member 2 | 0.692 |
PADI1 | TCHH | ENSP00000364620 | ENSP00000480484 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation; EF-hand domain containing | 0.649 |
PADI1 | TMEM35 | ENSP00000364620 | ENSP00000362021 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases | Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth | 0.519 |