C9orf89 protein (human) - STRING database

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Score

C9orf89

Chromosome 9 open reading frame 89 (183 aa)

Predicted Functional Partners:

MTX2

0.817

BCL10

0.770

CD244

0.635

NWD1

0.515

CRACR2B

0.455

CARD17

0.447

SUSD3

0.410

FGFBP2

0.402

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL10	C9orf89	ENSP00000359612	ENSP00000364613	B-cell lymphoma/leukemia 10; Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	Chromosome 9 open reading frame 89	0.770
C9orf89	BCL10	ENSP00000364613	ENSP00000359612	Chromosome 9 open reading frame 89	B-cell lymphoma/leukemia 10; Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1	0.770
C9orf89	CARD17	ENSP00000364613	ENSP00000364859	Chromosome 9 open reading frame 89	Caspase recruitment domain-containing protein 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation; Caspase recruitment domain containing	0.447
C9orf89	CD244	ENSP00000364613	ENSP00000357012	Chromosome 9 open reading frame 89	Natural killer cell receptor 2B4; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating functi [...]	0.635
C9orf89	CRACR2B	ENSP00000364613	ENSP00000435299	Chromosome 9 open reading frame 89	EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing	0.455
C9orf89	FGFBP2	ENSP00000364613	ENSP00000259989	Chromosome 9 open reading frame 89	Fibroblast growth factor binding protein 2	0.402
C9orf89	MTX2	ENSP00000364613	ENSP00000249442	Chromosome 9 open reading frame 89	Metaxin-2; Involved in transport of proteins into the mitochondrion	0.817
C9orf89	NWD1	ENSP00000364613	ENSP00000428579	Chromosome 9 open reading frame 89	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	0.515
C9orf89	SUSD3	ENSP00000364613	ENSP00000364621	Chromosome 9 open reading frame 89	Sushi domain-containing protein 3; May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration; Sushi domain containing	0.410
CARD17	C9orf89	ENSP00000364859	ENSP00000364613	Caspase recruitment domain-containing protein 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation; Caspase recruitment domain containing	Chromosome 9 open reading frame 89	0.447
CD244	C9orf89	ENSP00000357012	ENSP00000364613	Natural killer cell receptor 2B4; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating functi [...]	Chromosome 9 open reading frame 89	0.635
CD244	MTX2	ENSP00000357012	ENSP00000249442	Natural killer cell receptor 2B4; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating functi [...]	Metaxin-2; Involved in transport of proteins into the mitochondrion	0.823
CRACR2B	C9orf89	ENSP00000435299	ENSP00000364613	EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing	Chromosome 9 open reading frame 89	0.455
CRACR2B	FGFBP2	ENSP00000435299	ENSP00000259989	EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing	Fibroblast growth factor binding protein 2	0.440
FGFBP2	C9orf89	ENSP00000259989	ENSP00000364613	Fibroblast growth factor binding protein 2	Chromosome 9 open reading frame 89	0.402
FGFBP2	CRACR2B	ENSP00000259989	ENSP00000435299	Fibroblast growth factor binding protein 2	EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing	0.440
MTX2	C9orf89	ENSP00000249442	ENSP00000364613	Metaxin-2; Involved in transport of proteins into the mitochondrion	Chromosome 9 open reading frame 89	0.817
MTX2	CD244	ENSP00000249442	ENSP00000357012	Metaxin-2; Involved in transport of proteins into the mitochondrion	Natural killer cell receptor 2B4; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor. Activating functi [...]	0.823
NWD1	C9orf89	ENSP00000428579	ENSP00000364613	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	Chromosome 9 open reading frame 89	0.515
SUSD3	C9orf89	ENSP00000364621	ENSP00000364613	Sushi domain-containing protein 3; May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration; Sushi domain containing	Chromosome 9 open reading frame 89	0.410

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