| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCNJL | GRTP1 | ENSP00000377547 | ENSP00000364579 | Cyclin-J-like protein; Cyclin J like; Cyclins | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.549 |
| DCUN1D2 | GRTP1 | ENSP00000417706 | ENSP00000364579 | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.552 |
| GRTP1 | CCNJL | ENSP00000364579 | ENSP00000377547 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | Cyclin-J-like protein; Cyclin J like; Cyclins | 0.549 |
| GRTP1 | DCUN1D2 | ENSP00000364579 | ENSP00000417706 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity | 0.552 |
| GRTP1 | PLBD1 | ENSP00000364579 | ENSP00000240617 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | Phospholipase B-like 1; In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids | 0.674 |
| GRTP1 | RAB8A | ENSP00000364579 | ENSP00000300935 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.568 |
| GRTP1 | RAB8B | ENSP00000364579 | ENSP00000312734 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity); RAB, member RAS on [...] | 0.568 |
| GRTP1 | RHBDD2 | ENSP00000364579 | ENSP00000006777 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | Rhomboid domain containing 2; Belongs to the peptidase S54 family | 0.644 |
| GRTP1 | TBC1D13 | ENSP00000364579 | ENSP00000361731 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes | 0.573 |
| GRTP1 | TBC1D17 | ENSP00000364579 | ENSP00000221543 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known | 0.587 |
| GRTP1 | TBC1D20 | ENSP00000364579 | ENSP00000346139 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | 0.622 |
| GRTP1 | TBC1D22A | ENSP00000364579 | ENSP00000336724 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.665 |
| PLBD1 | GRTP1 | ENSP00000240617 | ENSP00000364579 | Phospholipase B-like 1; In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.674 |
| RAB8A | GRTP1 | ENSP00000300935 | ENSP00000364579 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.568 |
| RAB8A | RAB8B | ENSP00000300935 | ENSP00000312734 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity); RAB, member RAS on [...] | 0.971 |
| RAB8A | TBC1D17 | ENSP00000300935 | ENSP00000221543 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known | 0.961 |
| RAB8A | TBC1D20 | ENSP00000300935 | ENSP00000346139 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude | 0.646 |
| RAB8A | TBC1D22A | ENSP00000300935 | ENSP00000336724 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.451 |
| RAB8B | GRTP1 | ENSP00000312734 | ENSP00000364579 | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity); RAB, member RAS on [...] | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) | 0.568 |
| RAB8B | RAB8A | ENSP00000312734 | ENSP00000300935 | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity); RAB, member RAS on [...] | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] | 0.971 |
