• Version:
  • 11.0 [archived version]
STRINGSTRING
C12orf71 C12orf71 GPR155 GPR155 AJAP1 AJAP1 ASTL ASTL MPEG1 MPEG1 LYZL2 LYZL2 WFDC5 WFDC5 CLEC10A CLEC10A CLEC2B CLEC2B DEFB118 DEFB118 CLEC3A CLEC3A
"LYZL2" - Lysozyme-like protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
LYZL2Lysozyme-like protein 2; Lysozymes, c-type (194 aa)    
Predicted Functional Partners:
AJAP1
Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration (411 aa)
           
  0.585
ASTL
Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity); Belongs to the peptidase M12A family (431 aa)
     
   
  0.521
DEFB118
Beta-defensin 118; Has antibacterial activity; Defensins, beta (123 aa)
           
  0.498
C12orf71
Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71 (269 aa)
           
  0.496
CLEC3A
C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing (206 aa)
           
  0.473
CLEC2B
C-type lectin domain family 2 member B (149 aa)
           
  0.473
CLEC10A
C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These sugar moieties are known as Tn-Ag and are expressed in a variety of carcinoma cells; C-type lectin domain containing (316 aa)
           
  0.446
GPR155
Integral membrane protein GPR155; G protein-coupled receptor 155 (870 aa)
           
  0.426
WFDC5
WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing (123 aa)
           
  0.422
MPEG1
Macrophage-expressed gene 1 protein; Macrophage expressed 1 (716 aa)
     
   
  0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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