node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AADACL2 | AAED1 | ENSP00000348911 | ENSP00000364382 | Arylacetamide deacetylase-like 2; Arylacetamide deacetylase family; Belongs to the ’GDXG’ lipolytic enzyme family | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.537 |
AADACL3 | AAED1 | ENSP00000352268 | ENSP00000364382 | Arylacetamide deacetylase-like 3; Arylacetamide deacetylase family | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.570 |
AAED1 | AADACL2 | ENSP00000364382 | ENSP00000348911 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Arylacetamide deacetylase-like 2; Arylacetamide deacetylase family; Belongs to the ’GDXG’ lipolytic enzyme family | 0.537 |
AAED1 | AADACL3 | ENSP00000364382 | ENSP00000352268 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Arylacetamide deacetylase-like 3; Arylacetamide deacetylase family | 0.570 |
AAED1 | ANKRD16 | ENSP00000364382 | ENSP00000369436 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.543 |
AAED1 | FAM213A | ENSP00000364382 | ENSP00000482445 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Redox-regulatory protein FAM213A; Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway; Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily | 0.555 |
AAED1 | FBXL17 | ENSP00000364382 | ENSP00000437464 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 0.782 |
AAED1 | MRPS27 | ENSP00000364382 | ENSP00000426941 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth | 0.768 |
AAED1 | RNF122 | ENSP00000364382 | ENSP00000256257 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | 0.621 |
AAED1 | SMYD1 | ENSP00000364382 | ENSP00000393453 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.555 |
AAED1 | UBOX5 | ENSP00000364382 | ENSP00000217173 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates; Ring finger proteins | 0.758 |
AAED1 | ZNF367 | ENSP00000364382 | ENSP00000364405 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.832 |
ANKRD16 | AAED1 | ENSP00000369436 | ENSP00000364382 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.543 |
FAM213A | AAED1 | ENSP00000482445 | ENSP00000364382 | Redox-regulatory protein FAM213A; Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway; Belongs to the peroxiredoxin-like FAM213 family. FAM213A subfamily | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.555 |
FBXL17 | AAED1 | ENSP00000437464 | ENSP00000364382 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family | 0.782 |
FBXL17 | MRPS27 | ENSP00000437464 | ENSP00000426941 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | 28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth | 0.729 |
FBXL17 | RNF122 | ENSP00000437464 | ENSP00000256257 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins | 0.626 |
FBXL17 | SMYD1 | ENSP00000437464 | ENSP00000393453 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily | 0.622 |
FBXL17 | UBOX5 | ENSP00000437464 | ENSP00000217173 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates; Ring finger proteins | 0.753 |
FBXL17 | ZNF367 | ENSP00000437464 | ENSP00000364405 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type | 0.755 |