• Version:
  • 11.0 [archived version]
STRINGSTRING
BRIX1 BRIX1 MRTO4 MRTO4 NOP2 NOP2 NIFK NIFK EBNA1BP2 EBNA1BP2 RSL24D1 RSL24D1 FTSJ3 FTSJ3 NSA2 NSA2 GTPBP4 GTPBP4 SDAD1 SDAD1 PES1 PES1
"MRTO4" - mRNA turnover protein 4 homolog in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MRTO4mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes (239 aa)    
Predicted Functional Partners:
NSA2
Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) (260 aa)
     
 
  0.999
GTPBP4
Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily (634 aa)
     
 
  0.998
NIFK
Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing (293 aa)
     
 
  0.998
EBNA1BP2
Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family (361 aa)
     
 
  0.997
RSL24D1
Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukaryotic ribosomal protein eL24 family (163 aa)
     
 
  0.997
PES1
Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family (588 aa)
     
 
  0.997
BRIX1
Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit (353 aa)
     
 
  0.996
SDAD1
Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family (687 aa)
     
 
  0.996
NOP2
Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family (845 aa)
     
 
  0.995
FTSJ3
pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily (847 aa)
     
 
  0.995
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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