PQLC2 protein (human) - STRING database

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PQLC2

Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes (291 aa)

Predicted Functional Partners:

CTNS

0.874

FAM208B

0.651

EBNA1BP2

0.635

ZSWIM2

0.632

TMEM208

0.581

PQLC1

0.574

DUS2

0.549

TMEM44

0.539

MIER1

0.528

SLC38A6

0.497

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTNS	PQLC1	ENSP00000371294	ENSP00000380880	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	PQ-loop repeat-containing protein 1; PQ loop repeat containing 1	0.636
CTNS	PQLC2	ENSP00000371294	ENSP00000364295	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	0.874
DUS2	PQLC2	ENSP00000455229	ENSP00000364295	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	0.549
EBNA1BP2	PQLC2	ENSP00000407323	ENSP00000364295	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	0.635
EBNA1BP2	ZSWIM2	ENSP00000407323	ENSP00000295131	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes; Ring finger proteins	0.660
FAM208B	PQLC2	ENSP00000328426	ENSP00000364295	Protein FAM208B; Family with sequence similarity 208 member B; Belongs to the FAM208 family	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	0.651
FAM208B	TMEM208	ENSP00000328426	ENSP00000305892	Protein FAM208B; Family with sequence similarity 208 member B; Belongs to the FAM208 family	Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy	0.709
MIER1	PQLC2	ENSP00000383820	ENSP00000364295	Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing; Myb/SANT domain containing	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	0.528
PQLC1	CTNS	ENSP00000380880	ENSP00000371294	PQ-loop repeat-containing protein 1; PQ loop repeat containing 1	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	0.636
PQLC1	PQLC2	ENSP00000380880	ENSP00000364295	PQ-loop repeat-containing protein 1; PQ loop repeat containing 1	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	0.574
PQLC1	TMEM44	ENSP00000380880	ENSP00000376227	PQ-loop repeat-containing protein 1; PQ loop repeat containing 1	Transmembrane protein 44	0.747
PQLC2	CTNS	ENSP00000364295	ENSP00000371294	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family	0.874
PQLC2	DUS2	ENSP00000364295	ENSP00000455229	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR	0.549
PQLC2	EBNA1BP2	ENSP00000364295	ENSP00000407323	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	0.635
PQLC2	FAM208B	ENSP00000364295	ENSP00000328426	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Protein FAM208B; Family with sequence similarity 208 member B; Belongs to the FAM208 family	0.651
PQLC2	MIER1	ENSP00000364295	ENSP00000383820	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing; Myb/SANT domain containing	0.528
PQLC2	PQLC1	ENSP00000364295	ENSP00000380880	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	PQ-loop repeat-containing protein 1; PQ loop repeat containing 1	0.574
PQLC2	SLC38A6	ENSP00000364295	ENSP00000346959	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Probable sodium-coupled neutral amino acid transporter 6; Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate; Solute carriers	0.497
PQLC2	TMEM208	ENSP00000364295	ENSP00000305892	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy	0.581
PQLC2	TMEM44	ENSP00000364295	ENSP00000376227	Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes	Transmembrane protein 44	0.539

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