node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECE1 | EDN1 | ENSP00000364028 | ENSP00000368683 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.993 |
ECE1 | EDN2 | ENSP00000364028 | ENSP00000361668 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.669 |
ECE1 | EDN3 | ENSP00000364028 | ENSP00000337128 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.732 |
ECE1 | EDNRA | ENSP00000364028 | ENSP00000315011 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is- ET1 > ET2 >> ET3 | 0.731 |
ECE1 | EDNRB | ENSP00000364028 | ENSP00000366416 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | 0.735 |
ECE1 | IDE | ENSP00000364028 | ENSP00000265986 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia; M16 metallopeptidases | 0.674 |
ECE1 | LIAS | ENSP00000364028 | ENSP00000261434 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives | 0.626 |
ECE1 | NAGLU | ENSP00000364028 | ENSP00000225927 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate | 0.623 |
ECE1 | SPINT1 | ENSP00000364028 | ENSP00000342098 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.626 |
ECE1 | TSR1 | ENSP00000364028 | ENSP00000301364 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus | 0.625 |
EDN1 | ECE1 | ENSP00000368683 | ENSP00000364028 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | 0.993 |
EDN1 | EDN2 | ENSP00000368683 | ENSP00000361668 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.983 |
EDN1 | EDN3 | ENSP00000368683 | ENSP00000337128 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.924 |
EDN1 | EDNRA | ENSP00000368683 | ENSP00000315011 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is- ET1 > ET2 >> ET3 | 0.999 |
EDN1 | EDNRB | ENSP00000368683 | ENSP00000366416 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | 0.999 |
EDN2 | ECE1 | ENSP00000361668 | ENSP00000364028 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family | 0.669 |
EDN2 | EDN1 | ENSP00000361668 | ENSP00000368683 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family | 0.983 |
EDN2 | EDN3 | ENSP00000361668 | ENSP00000337128 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.921 |
EDN2 | EDNRA | ENSP00000361668 | ENSP00000315011 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is- ET1 > ET2 >> ET3 | 0.979 |
EDN2 | EDNRB | ENSP00000361668 | ENSP00000366416 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily | 0.986 |