node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSBG2 | LPPR1 | ENSP00000465589 | ENSP00000364008 | Long-chain-fatty-acid--CoA ligase ACSBG2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily | Lipid phosphate phosphatase-related protein type 1 | 0.495 |
ENPP3 | LPPR1 | ENSP00000406261 | ENSP00000364008 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD; CD molecules | Lipid phosphate phosphatase-related protein type 1 | 0.471 |
GREB1L | LPPR1 | ENSP00000464162 | ENSP00000364008 | GREB1-like protein; Growth regulation by estrogen in breast cancer 1 like; Belongs to the GREB1 family | Lipid phosphate phosphatase-related protein type 1 | 0.499 |
LPPR1 | ACSBG2 | ENSP00000364008 | ENSP00000465589 | Lipid phosphate phosphatase-related protein type 1 | Long-chain-fatty-acid--CoA ligase ACSBG2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis; Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily | 0.495 |
LPPR1 | ENPP3 | ENSP00000364008 | ENSP00000406261 | Lipid phosphate phosphatase-related protein type 1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD; CD molecules | 0.471 |
LPPR1 | GREB1L | ENSP00000364008 | ENSP00000464162 | Lipid phosphate phosphatase-related protein type 1 | GREB1-like protein; Growth regulation by estrogen in breast cancer 1 like; Belongs to the GREB1 family | 0.499 |
LPPR1 | LPPR3 | ENSP00000364008 | ENSP00000352962 | Lipid phosphate phosphatase-related protein type 1 | Lipid phosphate phosphatase-related protein type 3 | 0.555 |
LPPR1 | NEU2 | ENSP00000364008 | ENSP00000233840 | Lipid phosphate phosphatase-related protein type 1 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides | 0.527 |
LPPR1 | NGEF | ENSP00000364008 | ENSP00000264051 | Lipid phosphate phosphatase-related protein type 1 | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) | 0.617 |
LPPR1 | PODXL | ENSP00000364008 | ENSP00000367817 | Lipid phosphate phosphatase-related protein type 1 | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial pola [...] | 0.496 |
LPPR1 | RAB23 | ENSP00000364008 | ENSP00000417610 | Lipid phosphate phosphatase-related protein type 1 | Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 pr [...] | 0.527 |
LPPR1 | STX4 | ENSP00000364008 | ENSP00000317714 | Lipid phosphate phosphatase-related protein type 1 | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family | 0.550 |
LPPR1 | STXBP3 | ENSP00000364008 | ENSP00000359025 | Lipid phosphate phosphatase-related protein type 1 | Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes | 0.792 |
LPPR3 | LPPR1 | ENSP00000352962 | ENSP00000364008 | Lipid phosphate phosphatase-related protein type 3 | Lipid phosphate phosphatase-related protein type 1 | 0.555 |
NEU2 | LPPR1 | ENSP00000233840 | ENSP00000364008 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides | Lipid phosphate phosphatase-related protein type 1 | 0.527 |
NEU2 | NGEF | ENSP00000233840 | ENSP00000264051 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) | 0.417 |
NEU2 | PODXL | ENSP00000233840 | ENSP00000367817 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial pola [...] | 0.412 |
NGEF | LPPR1 | ENSP00000264051 | ENSP00000364008 | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) | Lipid phosphate phosphatase-related protein type 1 | 0.617 |
NGEF | NEU2 | ENSP00000264051 | ENSP00000233840 | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity) | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides | 0.417 |
PODXL | LPPR1 | ENSP00000367817 | ENSP00000364008 | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial pola [...] | Lipid phosphate phosphatase-related protein type 1 | 0.496 |