NIPSNAP3A protein (human) - STRING database

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Score

NIPSNAP3A

Nipsnap homolog 3A; Belongs to the NipSnap family (247 aa)

Predicted Functional Partners:

SPIC

0.900

ABCA1

0.649

C1orf122

0.645

LAMP1

0.546

HOOK3

0.545

ERI3

0.518

MANEA

0.502

DERA

0.484

HM13

0.477

PAK1IP1

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	NIPSNAP3A	ENSP00000363868	ENSP00000363899	ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transporter superfamily. ABCA family	Nipsnap homolog 3A; Belongs to the NipSnap family	0.649
ABCA1	SPIC	ENSP00000363868	ENSP00000448580	ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transporter superfamily. ABCA family	Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family	0.511
C1orf122	DERA	ENSP00000362133	ENSP00000416583	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation	0.516
C1orf122	ERI3	ENSP00000362133	ENSP00000361331	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	ERI1 exoribonuclease family member 3; Exonucleases	0.556
C1orf122	HM13	ENSP00000362133	ENSP00000381237	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	Histocompatibility minor 13	0.540
C1orf122	MANEA	ENSP00000362133	ENSP00000351669	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	Glycoprotein endo-alpha-1,2-mannosidase; Mannosidases endo-alpha	0.531
C1orf122	NIPSNAP3A	ENSP00000362133	ENSP00000363899	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	Nipsnap homolog 3A; Belongs to the NipSnap family	0.645
C1orf122	PAK1IP1	ENSP00000362133	ENSP00000368887	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly; WD repeat domain containing	0.516
DERA	C1orf122	ENSP00000416583	ENSP00000362133	Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	0.516
DERA	NIPSNAP3A	ENSP00000416583	ENSP00000363899	Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation	Nipsnap homolog 3A; Belongs to the NipSnap family	0.484
ERI3	C1orf122	ENSP00000361331	ENSP00000362133	ERI1 exoribonuclease family member 3; Exonucleases	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	0.556
ERI3	NIPSNAP3A	ENSP00000361331	ENSP00000363899	ERI1 exoribonuclease family member 3; Exonucleases	Nipsnap homolog 3A; Belongs to the NipSnap family	0.518
HM13	C1orf122	ENSP00000381237	ENSP00000362133	Histocompatibility minor 13	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	0.540
HM13	NIPSNAP3A	ENSP00000381237	ENSP00000363899	Histocompatibility minor 13	Nipsnap homolog 3A; Belongs to the NipSnap family	0.477
HM13	PAK1IP1	ENSP00000381237	ENSP00000368887	Histocompatibility minor 13	P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly; WD repeat domain containing	0.406
HOOK3	NIPSNAP3A	ENSP00000305699	ENSP00000363899	Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor c [...]	Nipsnap homolog 3A; Belongs to the NipSnap family	0.545
LAMP1	NIPSNAP3A	ENSP00000333298	ENSP00000363899	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Nipsnap homolog 3A; Belongs to the NipSnap family	0.546
LAMP1	SPIC	ENSP00000333298	ENSP00000448580	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family	0.575
MANEA	C1orf122	ENSP00000351669	ENSP00000362133	Glycoprotein endo-alpha-1,2-mannosidase; Mannosidases endo-alpha	Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122	0.531
MANEA	NIPSNAP3A	ENSP00000351669	ENSP00000363899	Glycoprotein endo-alpha-1,2-mannosidase; Mannosidases endo-alpha	Nipsnap homolog 3A; Belongs to the NipSnap family	0.502

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