NIPSNAP3B protein (human) - STRING database

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NIPSNAP3B

Nipsnap homolog 3B; Belongs to the NipSnap family (247 aa)

Predicted Functional Partners:

SPIC

0.835

ABCA1

0.650

SUSD1

0.622

SLC46A2

0.603

LAMP1

0.539

ZNF483

0.530

HHATL

0.525

TDRD3

0.516

ITK

0.510

ZNF462

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	NIPSNAP3B	ENSP00000363868	ENSP00000363894	ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transporter superfamily. ABCA family	Nipsnap homolog 3B; Belongs to the NipSnap family	0.650
ABCA1	SPIC	ENSP00000363868	ENSP00000448580	ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transporter superfamily. ABCA family	Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family	0.511
HHATL	NIPSNAP3B	ENSP00000405423	ENSP00000363894	Protein-cysteine N-palmitoyltransferase HHAT-like protein; Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN; Belongs to the membrane-bound acyltransferase family. HHAT subfamily	Nipsnap homolog 3B; Belongs to the NipSnap family	0.525
ITK	NIPSNAP3B	ENSP00000398655	ENSP00000363894	Tyrosine-protein kinase ITK/TSK; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the a [...]	Nipsnap homolog 3B; Belongs to the NipSnap family	0.510
LAMP1	NIPSNAP3B	ENSP00000333298	ENSP00000363894	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Nipsnap homolog 3B; Belongs to the NipSnap family	0.539
LAMP1	SPIC	ENSP00000333298	ENSP00000448580	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family	0.575
NIPSNAP3B	ABCA1	ENSP00000363894	ENSP00000363868	Nipsnap homolog 3B; Belongs to the NipSnap family	ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transporter superfamily. ABCA family	0.650
NIPSNAP3B	HHATL	ENSP00000363894	ENSP00000405423	Nipsnap homolog 3B; Belongs to the NipSnap family	Protein-cysteine N-palmitoyltransferase HHAT-like protein; Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN; Belongs to the membrane-bound acyltransferase family. HHAT subfamily	0.525
NIPSNAP3B	ITK	ENSP00000363894	ENSP00000398655	Nipsnap homolog 3B; Belongs to the NipSnap family	Tyrosine-protein kinase ITK/TSK; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the a [...]	0.510
NIPSNAP3B	LAMP1	ENSP00000363894	ENSP00000333298	Nipsnap homolog 3B; Belongs to the NipSnap family	Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules	0.539
NIPSNAP3B	SLC46A2	ENSP00000363894	ENSP00000363345	Nipsnap homolog 3B; Belongs to the NipSnap family	Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family	0.603
NIPSNAP3B	SPIC	ENSP00000363894	ENSP00000448580	Nipsnap homolog 3B; Belongs to the NipSnap family	Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5’-GAGGA[AT]-3’) that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression (By similarity); Belongs to the ETS family	0.835
NIPSNAP3B	SUSD1	ENSP00000363894	ENSP00000363382	Nipsnap homolog 3B; Belongs to the NipSnap family	Sushi domain containing 1	0.622
NIPSNAP3B	TDRD3	ENSP00000363894	ENSP00000440190	Nipsnap homolog 3B; Belongs to the NipSnap family	Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator- recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine- methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins; Tudor d [...]	0.516
NIPSNAP3B	ZNF462	ENSP00000363894	ENSP00000277225	Nipsnap homolog 3B; Belongs to the NipSnap family	Zinc finger protein 462; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.459
NIPSNAP3B	ZNF483	ENSP00000363894	ENSP00000311679	Nipsnap homolog 3B; Belongs to the NipSnap family	Zinc finger protein 483; May be involved in transcriptional regulation; SCAN domain containing	0.530
SLC46A2	NIPSNAP3B	ENSP00000363345	ENSP00000363894	Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family	Nipsnap homolog 3B; Belongs to the NipSnap family	0.603
SLC46A2	SUSD1	ENSP00000363345	ENSP00000363382	Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family	Sushi domain containing 1	0.782
SLC46A2	TDRD3	ENSP00000363345	ENSP00000440190	Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family	Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator- recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine- methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins; Tudor d [...]	0.706
SLC46A2	ZNF462	ENSP00000363345	ENSP00000277225	Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family	Zinc finger protein 462; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.560

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