node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP15 | MYO1G | ENSP00000295095 | ENSP00000258787 | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction; Pleckstrin homology domain containing | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | 0.604 |
ARHGAP15 | OXLD1 | ENSP00000295095 | ENSP00000363873 | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction; Pleckstrin homology domain containing | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.619 |
CARS2 | OXLD1 | ENSP00000257347 | ENSP00000363873 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.571 |
CARS2 | TRMT61B | ENSP00000257347 | ENSP00000302801 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family | tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial; Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC). Catalyzes the formation of 1- methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function. In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)- methyltransferase by [...] | 0.755 |
GRPEL2 | OXLD1 | ENSP00000329558 | ENSP00000363873 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.656 |
HIBCH | OXLD1 | ENSP00000352706 | ENSP00000363873 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.632 |
LSP1 | MYO1G | ENSP00000371194 | ENSP00000258787 | Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | 0.642 |
LSP1 | OXLD1 | ENSP00000371194 | ENSP00000363873 | Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.571 |
LSP1 | STX11 | ENSP00000371194 | ENSP00000356540 | Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network; Syntaxins | 0.495 |
MYO1G | ARHGAP15 | ENSP00000258787 | ENSP00000295095 | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction; Pleckstrin homology domain containing | 0.604 |
MYO1G | LSP1 | ENSP00000258787 | ENSP00000371194 | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis | 0.642 |
MYO1G | OXLD1 | ENSP00000258787 | ENSP00000363873 | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.626 |
MYO1G | STX11 | ENSP00000258787 | ENSP00000356540 | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent proce [...] | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network; Syntaxins | 0.566 |
OGFOD3 | OXLD1 | ENSP00000330075 | ENSP00000363873 | 2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 0.794 |
OGFOD3 | WDR45B | ENSP00000330075 | ENSP00000376139 | 2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family | WD repeat domain containing | 0.530 |
OXLD1 | ARHGAP15 | ENSP00000363873 | ENSP00000295095 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction; Pleckstrin homology domain containing | 0.619 |
OXLD1 | CARS2 | ENSP00000363873 | ENSP00000257347 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family | 0.571 |
OXLD1 | GRPEL2 | ENSP00000363873 | ENSP00000329558 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity); Belongs to the GrpE family | 0.656 |
OXLD1 | HIBCH | ENSP00000363873 | ENSP00000352706 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA | 0.632 |
OXLD1 | LSP1 | ENSP00000363873 | ENSP00000371194 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 | Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis | 0.571 |