| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BGN | DAG1 | ENSP00000327336 | ENSP00000442600 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.528 |
| BGN | DCN | ENSP00000327336 | ENSP00000052754 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | 0.933 |
| BGN | FGF2 | ENSP00000327336 | ENSP00000264498 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Fibroblast growth factor 2; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family | 0.679 |
| BGN | GPC1 | ENSP00000327336 | ENSP00000264039 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...] | 0.956 |
| BGN | GPC2 | ENSP00000327336 | ENSP00000292377 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Glypicans | 0.942 |
| BGN | GPC4 | ENSP00000327336 | ENSP00000359864 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity); Belongs to the glypican family | 0.944 |
| BGN | GPC6 | ENSP00000327336 | ENSP00000366246 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling; Belongs to the glypican family | 0.945 |
| BGN | HSPG2 | ENSP00000327336 | ENSP00000363827 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development; I-set domain containing | 0.977 |
| BGN | NID1 | ENSP00000327336 | ENSP00000264187 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | 0.577 |
| BGN | NID2 | ENSP00000327336 | ENSP00000216286 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | Nidogen-2; Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions | 0.527 |
| DAG1 | BGN | ENSP00000442600 | ENSP00000327336 | Dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | 0.528 |
| DAG1 | HSPG2 | ENSP00000442600 | ENSP00000363827 | Dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development; I-set domain containing | 0.992 |
| DCN | BGN | ENSP00000052754 | ENSP00000327336 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans | 0.933 |
| DCN | FGF2 | ENSP00000052754 | ENSP00000264498 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Fibroblast growth factor 2; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family | 0.829 |
| DCN | GPC1 | ENSP00000052754 | ENSP00000264039 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...] | 0.958 |
| DCN | GPC2 | ENSP00000052754 | ENSP00000292377 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Glypicans | 0.947 |
| DCN | GPC4 | ENSP00000052754 | ENSP00000359864 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity); Belongs to the glypican family | 0.944 |
| DCN | GPC6 | ENSP00000052754 | ENSP00000366246 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling; Belongs to the glypican family | 0.946 |
| DCN | HSPG2 | ENSP00000052754 | ENSP00000363827 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development; I-set domain containing | 0.975 |
| DCN | NID1 | ENSP00000052754 | ENSP00000264187 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions | 0.596 |
