| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMC1 | FAM206A | ENSP00000276569 | ENSP00000363753 | Armadillo repeat containing 1 | Protein Simiate; Family with sequence similarity 206 member A | 0.589 |
| FAM206A | ARMC1 | ENSP00000363753 | ENSP00000276569 | Protein Simiate; Family with sequence similarity 206 member A | Armadillo repeat containing 1 | 0.589 |
| FAM206A | FRRS1L | ENSP00000363753 | ENSP00000477141 | Protein Simiate; Family with sequence similarity 206 member A | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway | 0.897 |
| FAM206A | GXYLT1 | ENSP00000363753 | ENSP00000381666 | Protein Simiate; Family with sequence similarity 206 member A | Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose | 0.627 |
| FAM206A | OPRL1 | ENSP00000363753 | ENSP00000336764 | Protein Simiate; Family with sequence similarity 206 member A | Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception [...] | 0.578 |
| FAM206A | PEX26 | ENSP00000363753 | ENSP00000331106 | Protein Simiate; Family with sequence similarity 206 member A | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | 0.747 |
| FAM206A | PEX6 | ENSP00000363753 | ENSP00000303511 | Protein Simiate; Family with sequence similarity 206 member A | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.718 |
| FAM206A | PUS10 | ENSP00000363753 | ENSP00000326003 | Protein Simiate; Family with sequence similarity 206 member A | Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death | 0.873 |
| FAM206A | SYNJ2BP | ENSP00000363753 | ENSP00000256366 | Protein Simiate; Family with sequence similarity 206 member A | Synaptojanin-2-binding protein; Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction; PDZ domain containing | 0.800 |
| FAM206A | XRCC6BP1 | ENSP00000363753 | ENSP00000300145 | Protein Simiate; Family with sequence similarity 206 member A | Mitochondrial inner membrane protease ATP23 homolog; XRCC6 binding protein 1; Belongs to the peptidase M76 family | 0.633 |
| FAM206A | XXYLT1 | ENSP00000363753 | ENSP00000309640 | Protein Simiate; Family with sequence similarity 206 member A | Xyloside xylosyltransferase 1; Alpha-1,3-xylosyltransferase, which elongates the O- linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9; Glycosyltransferase family 8 | 0.691 |
| FRRS1L | FAM206A | ENSP00000477141 | ENSP00000363753 | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway | Protein Simiate; Family with sequence similarity 206 member A | 0.897 |
| GXYLT1 | FAM206A | ENSP00000381666 | ENSP00000363753 | Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose | Protein Simiate; Family with sequence similarity 206 member A | 0.627 |
| OPRL1 | FAM206A | ENSP00000336764 | ENSP00000363753 | Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception [...] | Protein Simiate; Family with sequence similarity 206 member A | 0.578 |
| PEX26 | FAM206A | ENSP00000331106 | ENSP00000363753 | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | Protein Simiate; Family with sequence similarity 206 member A | 0.747 |
| PEX26 | PEX6 | ENSP00000331106 | ENSP00000303511 | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | 0.993 |
| PEX26 | SYNJ2BP | ENSP00000331106 | ENSP00000256366 | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | Synaptojanin-2-binding protein; Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction; PDZ domain containing | 0.628 |
| PEX6 | FAM206A | ENSP00000303511 | ENSP00000363753 | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Protein Simiate; Family with sequence similarity 206 member A | 0.718 |
| PEX6 | PEX26 | ENSP00000303511 | ENSP00000331106 | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence; Peroxins | 0.993 |
| PEX6 | SYNJ2BP | ENSP00000303511 | ENSP00000256366 | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes | Synaptojanin-2-binding protein; Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction; PDZ domain containing | 0.602 |
