| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACAA1 | ACAT1 | ENSP00000333664 | ENSP00000265838 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 0.932 |
| ACAA1 | ACAT2 | ENSP00000333664 | ENSP00000356015 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 0.919 |
| ACAA1 | AUH | ENSP00000333664 | ENSP00000364883 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.420 |
| ACAA1 | BDH1 | ENSP00000333664 | ENSP00000376184 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.544 |
| ACAA1 | BDH2 | ENSP00000333664 | ENSP00000296424 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity); Short chain dehydrogenase/reductase superfamily | 0.430 |
| ACAA1 | HMGCL | ENSP00000333664 | ENSP00000363614 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism | 0.954 |
| ACAA1 | HMGCS1 | ENSP00000333664 | ENSP00000322706 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.970 |
| ACAA1 | HMGCS2 | ENSP00000333664 | ENSP00000358414 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.972 |
| ACAA1 | HSD17B4 | ENSP00000333664 | ENSP00000420914 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 0.998 |
| ACAA1 | OXCT1 | ENSP00000333664 | ENSP00000196371 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | Succinyl-CoA-3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate; Belongs to the 3-oxoacid CoA-transferase family | 0.516 |
| ACAT1 | ACAA1 | ENSP00000265838 | ENSP00000333664 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 | 0.932 |
| ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 | 0.947 |
| ACAT1 | AUH | ENSP00000265838 | ENSP00000364883 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5- dicarboxylate catabolism pathway. The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.435 |
| ACAT1 | BDH1 | ENSP00000265838 | ENSP00000376184 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family | 0.699 |
| ACAT1 | BDH2 | ENSP00000265838 | ENSP00000296424 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity); Short chain dehydrogenase/reductase superfamily | 0.447 |
| ACAT1 | HMGCL | ENSP00000265838 | ENSP00000363614 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism | 0.956 |
| ACAT1 | HMGCS1 | ENSP00000265838 | ENSP00000322706 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
| ACAT1 | HMGCS2 | ENSP00000265838 | ENSP00000358414 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.982 |
| ACAT1 | HSD17B4 | ENSP00000265838 | ENSP00000420914 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Short chain dehydrogenase/reductase superfamily | 0.424 |
| ACAT1 | OXCT1 | ENSP00000265838 | ENSP00000196371 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism | Succinyl-CoA-3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate; Belongs to the 3-oxoacid CoA-transferase family | 0.978 |
