node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARSA | CTSA | ENSP00000216124 | ENSP00000361562 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | 0.937 |
ARSA | FUCA1 | ENSP00000216124 | ENSP00000363603 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | 0.928 |
ARSA | GALNS | ENSP00000216124 | ENSP00000268695 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.977 |
ARSA | GLA | ENSP00000216124 | ENSP00000218516 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.946 |
ARSA | GLB1 | ENSP00000216124 | ENSP00000306920 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.952 |
ARSA | GM2A | ENSP00000216124 | ENSP00000349687 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.939 |
ARSA | GUSB | ENSP00000216124 | ENSP00000302728 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.954 |
ARSA | HEXB | ENSP00000216124 | ENSP00000261416 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.917 |
ARSA | MAN2B1 | ENSP00000216124 | ENSP00000395473 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages; Belongs to the glycosyl hydrolase 38 family | 0.917 |
ARSA | PRDX6 | ENSP00000216124 | ENSP00000342026 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.903 |
CTSA | ARSA | ENSP00000361562 | ENSP00000216124 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family | 0.937 |
CTSA | FUCA1 | ENSP00000361562 | ENSP00000363603 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins | 0.924 |
CTSA | GALNS | ENSP00000361562 | ENSP00000268695 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family | 0.947 |
CTSA | GLA | ENSP00000361562 | ENSP00000218516 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family | 0.967 |
CTSA | GLB1 | ENSP00000361562 | ENSP00000306920 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family | 0.993 |
CTSA | GM2A | ENSP00000361562 | ENSP00000349687 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.934 |
CTSA | GUSB | ENSP00000361562 | ENSP00000302728 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family | 0.923 |
CTSA | HEXB | ENSP00000361562 | ENSP00000261416 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; Belongs to the glycosyl hydrolase 20 family | 0.935 |
CTSA | MAN2B1 | ENSP00000361562 | ENSP00000395473 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages; Belongs to the glycosyl hydrolase 38 family | 0.934 |
CTSA | PRDX6 | ENSP00000361562 | ENSP00000342026 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] | 0.939 |