| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM50B | NAA60 | ENSP00000369627 | ENSP00000385903 | Protein FAM50B; Family with sequence similarity 50 member B | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the acet [...] | 0.521 |
| FAM50B | PEG3 | ENSP00000369627 | ENSP00000326581 | Protein FAM50B; Family with sequence similarity 50 member B | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.407 |
| FAM50B | ZDBF2 | ENSP00000369627 | ENSP00000363545 | Protein FAM50B; Family with sequence similarity 50 member B | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.530 |
| FAM50B | ZNF597 | ENSP00000369627 | ENSP00000301744 | Protein FAM50B; Family with sequence similarity 50 member B | Zinc finger protein 597; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.563 |
| GDAP1L1 | ZDBF2 | ENSP00000440498 | ENSP00000363545 | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.633 |
| GPR1 | ZDBF2 | ENSP00000480405 | ENSP00000363545 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1; G protein-coupled receptors, Class A orphans | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.627 |
| NAA60 | FAM50B | ENSP00000385903 | ENSP00000369627 | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the acet [...] | Protein FAM50B; Family with sequence similarity 50 member B | 0.521 |
| NAA60 | ZDBF2 | ENSP00000385903 | ENSP00000363545 | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the acet [...] | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.515 |
| NAA60 | ZNF597 | ENSP00000385903 | ENSP00000301744 | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences; Belongs to the acet [...] | Zinc finger protein 597; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.761 |
| PEG3 | FAM50B | ENSP00000326581 | ENSP00000369627 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | Protein FAM50B; Family with sequence similarity 50 member B | 0.407 |
| PEG3 | SNRPN | ENSP00000326581 | ENSP00000382972 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events; Sm spliceosomal proteins | 0.789 |
| PEG3 | ZDBF2 | ENSP00000326581 | ENSP00000363545 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.553 |
| RIOK2 | ZDBF2 | ENSP00000283109 | ENSP00000363545 | Serine/threonine-protein kinase RIO2; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre- ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its catalytic activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.628 |
| SENP6 | ZDBF2 | ENSP00000402527 | ENSP00000363545 | Sentrin-specific protease 6; Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1 [...] | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.822 |
| SNRPN | PEG3 | ENSP00000382972 | ENSP00000326581 | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events; Sm spliceosomal proteins | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.789 |
| SNRPN | ZDBF2 | ENSP00000382972 | ENSP00000363545 | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events; Sm spliceosomal proteins | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | 0.548 |
| SNRPN | ZFP57 | ENSP00000382972 | ENSP00000418259 | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events; Sm spliceosomal proteins | ZFP57 zinc finger protein; Zinc fingers C2H2-type | 0.629 |
| ZDBF2 | FAM50B | ENSP00000363545 | ENSP00000369627 | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | Protein FAM50B; Family with sequence similarity 50 member B | 0.530 |
| ZDBF2 | GDAP1L1 | ENSP00000363545 | ENSP00000440498 | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 | 0.633 |
| ZDBF2 | GPR1 | ENSP00000363545 | ENSP00000480405 | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as a coreceptor for HIV-1; G protein-coupled receptors, Class A orphans | 0.627 |
