• Version:
  • 11.0 [archived version]
STRINGSTRING
UFC1 UFC1 LRRC7 LRRC7 PGM5 PGM5 MDH1B MDH1B OGDHL OGDHL TPI1 TPI1 MDH2 MDH2 PGK2 PGK2 FBP1 FBP1 PKLR PKLR PGM1 PGM1
"MDH1B" - Malate dehydrogenase 1B in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MDH1BMalate dehydrogenase 1B (518 aa)    
Predicted Functional Partners:
UFC1
Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage (167 aa)
           
  0.721
FBP1
Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa)
     
 
  0.684
MDH2
Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 (338 aa)
     
   
  0.682
PKLR
Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family (574 aa)
   
 
  0.673
OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial; Oxoglutarate dehydrogenase like; Belongs to the alpha-ketoglutarate dehydrogenase family (1010 aa)
   
   
  0.640
PGM1
Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family (580 aa)
     
 
  0.639
PGM5
Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity (567 aa)
     
 
  0.633
PGK2
Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family (417 aa)
   
 
  0.627
LRRC7
Leucine-rich repeat-containing protein 7; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression; Belongs to the LAP (LRR and PDZ) protein family (1537 aa)
           
  0.617
TPI1
Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family (286 aa)
   
   
  0.616
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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