node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FBP1 | MDH1B | ENSP00000408025 | ENSP00000363533 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | Malate dehydrogenase 1B | 0.684 |
FBP1 | MDH2 | ENSP00000408025 | ENSP00000327070 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 | 0.743 |
FBP1 | PGK2 | ENSP00000408025 | ENSP00000305995 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.548 |
FBP1 | PGM1 | ENSP00000408025 | ENSP00000360124 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.401 |
FBP1 | PKLR | ENSP00000408025 | ENSP00000339933 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family | 0.749 |
FBP1 | TPI1 | ENSP00000408025 | ENSP00000229270 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family | 0.723 |
LRRC7 | MDH1B | ENSP00000035383 | ENSP00000363533 | Leucine-rich repeat-containing protein 7; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression; Belongs to the LAP (LRR and PDZ) protein family | Malate dehydrogenase 1B | 0.617 |
MDH1B | FBP1 | ENSP00000363533 | ENSP00000408025 | Malate dehydrogenase 1B | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | 0.684 |
MDH1B | LRRC7 | ENSP00000363533 | ENSP00000035383 | Malate dehydrogenase 1B | Leucine-rich repeat-containing protein 7; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression; Belongs to the LAP (LRR and PDZ) protein family | 0.617 |
MDH1B | MDH2 | ENSP00000363533 | ENSP00000327070 | Malate dehydrogenase 1B | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 | 0.682 |
MDH1B | OGDHL | ENSP00000363533 | ENSP00000363216 | Malate dehydrogenase 1B | 2-oxoglutarate dehydrogenase-like, mitochondrial; Oxoglutarate dehydrogenase like; Belongs to the alpha-ketoglutarate dehydrogenase family | 0.640 |
MDH1B | PGK2 | ENSP00000363533 | ENSP00000305995 | Malate dehydrogenase 1B | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family | 0.627 |
MDH1B | PGM1 | ENSP00000363533 | ENSP00000360124 | Malate dehydrogenase 1B | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family | 0.639 |
MDH1B | PGM5 | ENSP00000363533 | ENSP00000379678 | Malate dehydrogenase 1B | Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity | 0.633 |
MDH1B | PKLR | ENSP00000363533 | ENSP00000339933 | Malate dehydrogenase 1B | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family | 0.673 |
MDH1B | TPI1 | ENSP00000363533 | ENSP00000229270 | Malate dehydrogenase 1B | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family | 0.616 |
MDH1B | UFC1 | ENSP00000363533 | ENSP00000356982 | Malate dehydrogenase 1B | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage | 0.721 |
MDH2 | FBP1 | ENSP00000327070 | ENSP00000408025 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] | 0.743 |
MDH2 | MDH1B | ENSP00000327070 | ENSP00000363533 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 | Malate dehydrogenase 1B | 0.682 |
MDH2 | OGDHL | ENSP00000327070 | ENSP00000363216 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 | 2-oxoglutarate dehydrogenase-like, mitochondrial; Oxoglutarate dehydrogenase like; Belongs to the alpha-ketoglutarate dehydrogenase family | 0.611 |