FAM83C protein (human) - STRING database

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FAM83C

Protein FAM83C; May play a role in MAPK signaling (747 aa)

Predicted Functional Partners:

SLCO5A1

0.679

AKR7A3

0.485

MMP24

0.446

EIF6

0.445

ARL11

0.433

GGT7

0.431

EDEM2

0.414

UQCC1

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR7A3	FAM83C	ENSP00000355377	ENSP00000363529	Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen; Aldo-keto reductases	Protein FAM83C; May play a role in MAPK signaling	0.485
ARL11	FAM83C	ENSP00000282026	ENSP00000363529	ADP-ribosylation factor-like protein 11; May play a role in apoptosis. May act as a tumor suppressor; Belongs to the small GTPase superfamily. Arf family	Protein FAM83C; May play a role in MAPK signaling	0.433
EDEM2	FAM83C	ENSP00000363616	ENSP00000363529	ER degradation-enhancing alpha-mannosidase-like protein 2; Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle; Belongs to the glycosyl hydrolase 47 family	Protein FAM83C; May play a role in MAPK signaling	0.414
EIF6	FAM83C	ENSP00000363574	ENSP00000363529	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...]	Protein FAM83C; May play a role in MAPK signaling	0.445
FAM83C	AKR7A3	ENSP00000363529	ENSP00000355377	Protein FAM83C; May play a role in MAPK signaling	Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen; Aldo-keto reductases	0.485
FAM83C	ARL11	ENSP00000363529	ENSP00000282026	Protein FAM83C; May play a role in MAPK signaling	ADP-ribosylation factor-like protein 11; May play a role in apoptosis. May act as a tumor suppressor; Belongs to the small GTPase superfamily. Arf family	0.433
FAM83C	EDEM2	ENSP00000363529	ENSP00000363616	Protein FAM83C; May play a role in MAPK signaling	ER degradation-enhancing alpha-mannosidase-like protein 2; Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2. Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle; Belongs to the glycosyl hydrolase 47 family	0.414
FAM83C	EIF6	ENSP00000363529	ENSP00000363574	Protein FAM83C; May play a role in MAPK signaling	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, control [...]	0.445
FAM83C	GGT7	ENSP00000363529	ENSP00000338964	Protein FAM83C; May play a role in MAPK signaling	Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases	0.431
FAM83C	MMP24	ENSP00000363529	ENSP00000246186	Protein FAM83C; May play a role in MAPK signaling	Matrix metalloproteinase-24; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate th [...]	0.446
FAM83C	SLCO5A1	ENSP00000363529	ENSP00000260126	Protein FAM83C; May play a role in MAPK signaling	Solute carrier organic anion transporter family member 5A1; Belongs to the organo anion transporter (TC 2.A.60) family	0.679
FAM83C	UQCC1	ENSP00000363529	ENSP00000363506	Protein FAM83C; May play a role in MAPK signaling	Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability; Belongs to the CBP3 family	0.400
GGT7	FAM83C	ENSP00000338964	ENSP00000363529	Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases	Protein FAM83C; May play a role in MAPK signaling	0.431
MMP24	FAM83C	ENSP00000246186	ENSP00000363529	Matrix metalloproteinase-24; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate th [...]	Protein FAM83C; May play a role in MAPK signaling	0.446
SLCO5A1	FAM83C	ENSP00000260126	ENSP00000363529	Solute carrier organic anion transporter family member 5A1; Belongs to the organo anion transporter (TC 2.A.60) family	Protein FAM83C; May play a role in MAPK signaling	0.679
UQCC1	FAM83C	ENSP00000363506	ENSP00000363529	Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability; Belongs to the CBP3 family	Protein FAM83C; May play a role in MAPK signaling	0.400

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