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  • 11.0 [archived version]
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KRTAP5-2 KRTAP5-2 WBSCR16 WBSCR16 SYN1 SYN1 RHCE RHCE TMEM57 TMEM57 TMEM50A TMEM50A RSRP1 RSRP1 SBNO1 SBNO1 SYF2 SYF2 MEMO1 MEMO1 NME3 NME3
"TMEM57" - Macoilin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
TMEM57Macoilin; Transmembrane protein 57 (664 aa)    
Predicted Functional Partners:
TMEM50A
Transmembrane protein 50A (157 aa)
           
  0.793
SYN1
Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level; Synapsins (705 aa)
           
  0.749
SYF2
Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family (243 aa)
           
  0.730
RSRP1
Arginine and serine rich protein 1; Belongs to the RSRP family (290 aa)
           
  0.723
KRTAP5-2
Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family (177 aa)
       
      0.711
MEMO1
Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration (297 aa)
           
  0.693
SBNO1
Strawberry notch homolog 1 (1393 aa)
     
   
  0.686
RHCE
Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Blood group antigens (417 aa)
           
  0.686
NME3
Nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis; NME/NM23 family (169 aa)
           
  0.626
WBSCR16
RCC1-like G exchanging factor-like protein; Williams-Beuren syndrome chromosome region 16 (464 aa)
           
  0.622
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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