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STRINGSTRING
COG1 COG1 MGAT1 MGAT1 COG2 COG2 MAN2A2 MAN2A2 COG6 COG6 COG5 COG5 MAN1C1 MAN1C1 MAN2A1 MAN2A1 COG7 COG7 COG4 COG4 GANAB GANAB
"MAN1C1" - Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MAN1C1Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc (630 aa)    
Predicted Functional Partners:
MAN2A2
Alpha-mannosidase 2x; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway; Mannosidases alpha class 2 (1150 aa)
      
 
  0.963
MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans; Mannosyl-glycoprotein N-acetylglucosaminyltransferases (445 aa)
        
  0.953
MAN2A1
Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway; Belongs to the glycosyl hydrolase 38 family (1144 aa)
      
 
  0.944
COG4
Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1; Belongs to the COG4 family (789 aa)
        
  0.933
COG7
Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function; Components of oligomeric golgi complex (770 aa)
      
 
  0.910
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Components of oligomeric golgi complex (657 aa)
      
  0.908
COG5
Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family (860 aa)
          
  0.908
GANAB
Neutral alpha-glucosidase AB; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia; Belongs to the glycosyl hydrolase 31 family (966 aa)
      
 
  0.908
COG1
Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function; Components of oligomeric golgi complex (980 aa)
          
  0.907
COG2
Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family (738 aa)
          
  0.906
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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