• Version:
  • 11.0 [archived version]
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SLC35B4 SLC35B4 SLC1A7 SLC1A7 SLC16A2 SLC16A2 CHIC1 CHIC1 GGTLC3 GGTLC3 THOC7 THOC7 SLC7A3 SLC7A3 CAT CAT SLC22A31 SLC22A31 COQ7 COQ7 SLC7A13 SLC7A13
"SLC7A3" - Cationic amino acid transporter 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
SLC7A3Cationic amino acid transporter 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family (619 aa)    
Predicted Functional Partners:
SLC1A7
Amino acid transporter; Solute carrier family 1 member 7 (619 aa)
       
 
  0.750
COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner; Belongs to the COQ7 family (217 aa)
           
  0.747
SLC7A13
Solute carrier family 7 member 13; Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner; Belongs to the amino acid-polyamine-organocation (APC) superfamily (470 aa)
   
 
 
  0.715
THOC7
THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cytoplasm vi [...] (204 aa)
           
  0.674
SLC16A2
Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family (539 aa)
           
  0.667
SLC22A31
Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions; Solute carriers (338 aa)
     
 
  0.587
SLC35B4
UDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily (331 aa)
           
  0.575
CHIC1
Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family (224 aa)
     
   
  0.566
CAT
Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells; Belongs to the catalase family (527 aa)
     
 
  0.547
GGTLC3
Gamma-glutamyltransferase light chain family member 3; Gamma-glutamyltransferases (225 aa)
     
   
  0.529
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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