| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG101 | ATG12 | ENSP00000338990 | ENSP00000425107 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes | 0.892 |
| ATG101 | ATG3 | ENSP00000338990 | ENSP00000283290 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjug [...] | 0.887 |
| ATG101 | PDIK1L | ENSP00000338990 | ENSP00000363389 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.595 |
| ATG12 | ATG101 | ENSP00000425107 | ENSP00000338990 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family | 0.892 |
| ATG12 | ATG3 | ENSP00000425107 | ENSP00000283290 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjug [...] | 0.999 |
| ATG12 | PDIK1L | ENSP00000425107 | ENSP00000363389 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.564 |
| ATG3 | ATG101 | ENSP00000283290 | ENSP00000338990 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjug [...] | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family | 0.887 |
| ATG3 | ATG12 | ENSP00000283290 | ENSP00000425107 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjug [...] | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes | 0.999 |
| ATG3 | PDIK1L | ENSP00000283290 | ENSP00000363389 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjug [...] | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.585 |
| AWAT1 | PDIK1L | ENSP00000363645 | ENSP00000363389 | Acyl-CoA wax alcohol acyltransferase 1; Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20); Diacylglycerol O-acyltransferase 2 family | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.708 |
| CSNK1D | PDIK1L | ENSP00000324464 | ENSP00000363389 | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.561 |
| GORAB | PDIK1L | ENSP00000356737 | ENSP00000363389 | Golgin, RAB6 interacting | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.555 |
| GORAB | PTPRK | ENSP00000356737 | ENSP00000357196 | Golgin, RAB6 interacting | Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa; Fibronectin type III domain containing | 0.452 |
| NIPSNAP1 | PDIK1L | ENSP00000216121 | ENSP00000363389 | Nipsnap homolog 1 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | 0.592 |
| NIPSNAP1 | TAF1B | ENSP00000216121 | ENSP00000263663 | Nipsnap homolog 1 | TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3; Belongs to the RRN7/TAF1B family | 0.632 |
| PDIK1L | ATG101 | ENSP00000363389 | ENSP00000338990 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family | 0.595 |
| PDIK1L | ATG12 | ENSP00000363389 | ENSP00000425107 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes | 0.564 |
| PDIK1L | ATG3 | ENSP00000363389 | ENSP00000283290 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12- ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjug [...] | 0.585 |
| PDIK1L | AWAT1 | ENSP00000363389 | ENSP00000363645 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Acyl-CoA wax alcohol acyltransferase 1; Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20); Diacylglycerol O-acyltransferase 2 family | 0.708 |
| PDIK1L | CSNK1D | ENSP00000363389 | ENSP00000324464 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] | 0.561 |
