node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SNX30 | SNX32 | ENSP00000363349 | ENSP00000310620 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | 0.651 |
SNX30 | SNX4 | ENSP00000363349 | ENSP00000251775 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nexin family | 0.747 |
SNX30 | SNX6 | ENSP00000363349 | ENSP00000355217 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | 0.633 |
SNX30 | ULK1 | ENSP00000363349 | ENSP00000324560 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, lead [...] | 0.520 |
SNX30 | ULK2 | ENSP00000363349 | ENSP00000378914 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy- acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG [...] | 0.520 |
SNX30 | ULK3 | ENSP00000363349 | ENSP00000400312 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand- interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH- dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] | 0.520 |
SNX30 | VPS26A | ENSP00000363349 | ENSP00000362480 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.531 |
SNX30 | VPS26B | ENSP00000363349 | ENSP00000281187 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.531 |
SNX30 | VPS29 | ENSP00000363349 | ENSP00000480853 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | 0.573 |
SNX30 | VPS35 | ENSP00000363349 | ENSP00000299138 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.600 |
SNX32 | SNX30 | ENSP00000310620 | ENSP00000363349 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | 0.651 |
SNX32 | SNX4 | ENSP00000310620 | ENSP00000251775 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nexin family | 0.680 |
SNX32 | SNX6 | ENSP00000310620 | ENSP00000355217 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | 0.860 |
SNX32 | VPS26A | ENSP00000310620 | ENSP00000362480 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.658 |
SNX32 | VPS26B | ENSP00000310620 | ENSP00000281187 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] | 0.686 |
SNX32 | VPS29 | ENSP00000310620 | ENSP00000480853 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo [...] | 0.713 |
SNX32 | VPS35 | ENSP00000310620 | ENSP00000299138 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.655 |
SNX4 | SNX30 | ENSP00000251775 | ENSP00000363349 | Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nexin family | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related | 0.747 |
SNX4 | SNX32 | ENSP00000251775 | ENSP00000310620 | Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nexin family | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing | 0.680 |
SNX4 | SNX6 | ENSP00000251775 | ENSP00000355217 | Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nexin family | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transp [...] | 0.912 |