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  • 11.0 [archived version]
STRINGSTRING
TMBIM1 TMBIM1 ZNF142 ZNF142 STK36 STK36 TTLL7 TTLL7 CDK5R2 CDK5R2 RUFY4 RUFY4 TRAPPC9 TRAPPC9 AMPD3 AMPD3 UAP1L1 UAP1L1 RUFY2 RUFY2 RAB33A RAB33A
"RUFY4" - RUN and FYVE domain containing 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
RUFY4RUN and FYVE domain containing 4; Zinc fingers FYVE-type (607 aa)    
Predicted Functional Partners:
RUFY2
RUN and FYVE domain containing 2; Zinc fingers FYVE-type (641 aa)
            
  0.761
ZNF142
Zinc finger protein 142; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1687 aa)
            
  0.732
CDK5R2
Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII (367 aa)
            
  0.723
UAP1L1
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 (507 aa)
            
  0.678
STK36
Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] (1315 aa)
            
  0.663
TMBIM1
Protein lifeguard 3; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling; Transmembrane BAX inhibitor motif containing (311 aa)
      
   
  0.625
TTLL7
Tubulin polyglutamylase TTLL7; Polyglutamylase which preferentially modifies beta- tubulin. Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules. Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity); Belongs to the tubulin--tyrosine ligase family (887 aa)
      
   
  0.557
RAB33A
Ras-related protein Rab-33A; RAB33A, member RAS oncogene family (237 aa)
            
  0.539
TRAPPC9
Trafficking protein particle complex subunit 9; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the NIBP family (1246 aa)
      
 
  0.531
AMPD3
AMP deaminase 3; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family (776 aa)
      
   
  0.501
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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